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a type of acidophil found in the anterior lobe of the pituitary gland that secretes corticotropin; it is synthesized as a large prohormone containing both corticotropin and β-lipotropin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
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An aggressive silent corticotrope cell pituitary adenoma, subtype 2, that progressed to carcinoma despite temozolomide administration was treated with the anti-VEGF monoclonal antibody bevacizumab for 26 months with stabilization of disease as documented on serial MRI and PET scans [94].
Pituitary adenomas can be derived from a single mutant cell of five differentiated cell types within pituitary gland: somatotropes, lactotropes, corticotropes, thyrotropes, and gonadotropes, which, respectively, secrete growth hormone (GH), prolactin (PRL), adrenocorticotrophic hormone (ACTH), thyroid-stimulating hormone (TSH), and gonadotropins (follicle-stimulating hormone (FSH) and luteinizing hormone (LH)).
SP22 was not observed in large gonadotropes or corticotropes. Additional slides were fluorescently co-labeled with SP22 and one of the AP hormones and examined by confocal microscopy.
The rare cell types, including corticotropes and thyrotropes (Figure 3), showed similar changes at the corresponding time points.