Influence of systemic corticotherapy
on the triggering of pityriasis versicolor.
Beyond the therapeutic elements (antibiotherapy, fluid expansion, corticotherapy
and red blood cell transfusion) included in EGDT for sepsis, the authors highlighted two key-points to reduce mortality: the early identification of sepsis and the time-lapse to therapeutics initiation.
In 2003, she received follow-up care in the Rheumatology Department at the Hospital del Mar/Pare de Salut Mar (Barcelona), where she started treatment with Dolquine (hydroxychloroquine) at a dose of 400 mg/day Corticotherapy
was withdrawn, with no need for reintroduction at any time during her follow-up.
It is suggested to continue systemic corticotherapy
for 6-8 weeks to treat skin and visceral infections and to prevent the relapses.
We performed a lumbar puncture and started intravenous corticotherapy
. CSF contained 127 leukocytes (61% lymphocytes) and showed hypoglycorrhachia.
The patient evolved with a rapid and significant recovery of her skin rash without the need of continued corticotherapy
after suspending the vancomycin.
More specifically, systemic disorders, such as diabetes, immunosuppression, and venous stasis as well as those resulting from external agents, such as the use of corticotherapy
and smoking, can hinder the early closure of the wound.
Pharmacological resources include, among others, corticotherapy
, tranexamic acid, thalidomide, cyproheptadine, calcitonin, with results which are difficult to quantify.
hospitalization before admission to ICU, longer length of ICU stay, prior use of arterial catheters, history of septic shock, prior use of empirical antibiotic therapy, prior use of third generation cephalosporins, prior use of imipenem, previous use of amikacin, previous use of colistin, previous use of glycopeptide antibiotics, administration of more than two antibiotics prior to infections, previous corticotherapy
, and duration of empirical antibiotic treatment [greater than or equal to] 5 days.
Local corticosteroid ointments and short-term oral corticotherapy
at a low dose or phototherapy is the treatment of choice.
Breakthrough Therapy Designation status was granted based on data from a Roche-supported randomized trial conducted in France (Comparison Between Rituximab Treatment and General Corticotherapy
Treatment in Patients With Pemphigus), which evaluated Rituxan plus oral corticosteroid treatment compared to CS as a first-line treatment in patients with moderate to severe pemphigus.
The "step-up" approach requires to start treatment with aminosalicylates (salazopirin or mesalazine) and, in case of therapeutic failure, corticotherapy
followed by immunosuppressant treatment with azathioprine, cyclosporine, 6-mercaptopurine or methotrexate.