Corticosteroids


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Related to Corticosteroids: prednisone, Topical corticosteroids

Corticosteroids

 

Definition

Corticosteroids are group of natural and synthetic analogues of the hormones secreted by the hypothalamic-anterior pituitary-adrenocortical (HPA) axis, more commonly referred to as the pituitary gland. These include glucocorticoids, which are anti-inflammatory agents with a large number of other functions; mineralocorticoids, which control salt and water balance primarily through action on the kidneys; and corticotropins, which control secretion of hormones by the pituitary gland.

Purpose

Glucocorticoids have multiple effects, and are used for a large number of conditions. They affect glucose utilization, fat metabolism, and bone development, and are potent anti-inflammatory agents. They may be used for replacement of natural hormones in patients with pituitary deficiency (Addison's disease), as well as for a wide number of other conditions including, but not limited to, arthritis, asthma, anemia, various cancers, and skin inflammations. Additional uses include inhibition of nausea and vomiting after chemotherapy, treatment of septic shock, treatment of spinal cord injuries, and treatment of hirisutism (excessive hair growth). The choice of drug will vary with the condition. Cortisone and hydrocortisone, which have both glucocorticoid and mineralocorticoid effects, are the drugs of choice for replacement therapy of natural hormone deficiency. Synthetic compounds, which have greater anti-inflammatory effects and less effect on salt and water balance, are usually preferred for other purposes. These compounds include dexamethasone, which is almost exclusively glucocorticoid in its actions, as well as prednisone, prednisolone, betamethasone, trimacinolone, and others. Glucocorticoids are formulated in oral dosage forms, topical creams and ointments, oral and nasal inhalations, rectal foams, and ear and eye drops.
Mineralocorticoids control the retention of sodium in the kidneys. In mineralocorticoid deficiency, there is excessive loss of sodium through the kidneys, with resulting water loss. Fludrocortisone (Florinef) is the only drug available for treatment of mineralocorticoid deficiency, and is available only in an oral dosage form.
Corticotropin (ACTH, adrenocorticotropic hormone) stimulates the pituitary gland to release cortisone. A deficiency of corticotropic hormone will have the same effects as a deficiency of cortisone. The hormone, which is available under the brand names Acthar and Actrel, is used for diagnostic testing, to determine the cause of a glucocorticoid deficiency, but is rarely used for replacement therapy since direct administration of glucocorticoids may be easier and offers better control over dosages.

Recommended dosage

The dosage of glucocorticoids varies with the drug, route of administration, condition being treated, and patient. Consult specific references.
Fludrocortisone, for use in replacement therapy, is normally dosed at 0.1 mg/day. Some patients require higher doses. It should normally be administered in conjunction with cortisone or hydrocortisone.
ACTH, when used for diagnostic purposes, is given as 10 to 25 units dissolved in 500 ml of 5% dextrose injection infused IV over eight hours. A long-acting form, which may be used for replacement therapy, is given by subcutaneous (SC) or intramuscular (IM) injection at a dose of 40 to 80 units every 24-72 hours.

Precautions

Glucocorticoids

The most significant risk associated with administration of glucocorticoids is suppression of natural corticosteroid secretion. When the hormones are administered, they suppress the secretion of ACTH, which in turn reduces the secretion of the natural hormones. The extent of suppression varies with dose, drug potency, duration of treatment, and individual patient response. While suppression is seen primarily with drugs administered systemically, it can also occur with topical drugs such as creams and ointments, or drugs administered by inhalation. Abrupt cessation of corticosteroids may result in acute adrenal crisis (Addisonian crisis) that is marked by dehydration with severe vomiting and diarrhea, hypotension, and loss of consciousness. Acute adrenal crisis is potentially fatal.
Chronic overdose of glucocorticoids leads to Cushingoid syndrome, which is clinically identical to Cushing's syndrome and differs only in that in Cushingoid the excessive steroids are from drug therapy rather than excessive glandular secretion. Symptoms vary, but most people have upper body obesity, rounded face, increased fat around the neck, and thinning arms and legs. In its later stages, this condition leads to weakening of bones and muscles with rib and spinal column fractures.
The short term adverse effects of corticosteroids are generally mild, and include indigestion, increased appetite, insomnia, and nervousness. There are also a very large number of infrequent adverse reactions, the most significant of which is drug-induced paranoia. Delirium, depression, menstrual irregularity, and increased hair growth are also possible. Consult detailed reviews for further information.
Long-term use of topical glucocorticoids can result in thinning of the skin. Oral steroid inhalations may cause fungal overgrowth in the oral cavity. Patients must be instructed to rinse their mouths carefully after each dose. Corticosteroids are pregnancy category C. The drugs have caused congenital malformations in animal studies, including cleft palate. Breastfeeding should be avoided.

Mineralocorticoids

Because fludrocortisone has glucocorticoid activity as well as mineralocorticoid action, the same hazards and precautions apply to fludrocortisone as to the glucocorticoids. Overdose of fludrocortisone may also cause edema, hypertension and congestive heart failure.
Corticotropin has all the same risks as the glucocorticoids. Prolonged use may cause reduced response to the stimulatory effects of corticotropin.

Warnings and contraindications

Use corticosteroids with caution in patients with the following conditions:
  • osteoporosis or any other bone disease
  • current or past tuberculosis
  • glaucoma or cataracts
  • infections of any type (virus, bacteria, fungus, amoeba)
  • sores in the nose or recent nose surgery (if using nasal spray forms of corticosteroids)
  • underactive or overactive thyroid
  • liver disease
  • stomach or intestine problems
  • diabetes
  • heart disease
  • high blood pressure
  • high cholesterol
  • kidney disease or kidney stones
  • myasthenia gravis
  • systemic lupus erythematosus (SLE)
  • emotional problems
  • skin conditions that cause the skin to be thinner and bruise more easily

Interactions

Corticosteroids have many drug interactions. Consult specific references.

Resources

Organizations

American Academy of Allergy, Asthma and Immunology. 611 East Wells Street, Milwaukee, WI 53202. (414) 272-6071. http://www.aaaai.org.
Asthma and Allergy Foundation of America. 1125 15th Street NW, Suite 502, Washington, DC 20005. (800) 727-8462. http://www.aafa.org.
National Heart, Lung and Blood Institute. National Institutes of Health, P.O. Box 30105, Bethesda, MD 20824-0105. (301) 251-1222. 〈http://www.nhlbi.nih.gov/nhlbi/nhlbi.htm〉.

Key terms

Hallucination — A false or distorted perception of objects, sounds, or events that seems real. Hallucinations usually result from drugs or mental disorders.
Hormone — A substance that is produced in one part of the body, then travels through the bloodstream to another part of the body where it has its effect.
Inflammation — Pain, redness, swelling, and heat that usually develop in response to injury or illness.
Ointment — A thick, spreadable substance that contains medicine and is meant to be used on the outside of the body.
Pregnancy category — A system of classifying drugs according to their established risks for use during pregnancy. Category A: controlled human studies have demonstrated no fetal risk. Category B: animal studies indicate no fetal risk, but no human studies; or adverse effects in animals, but not in well-controlled human studies. Category C: no adequate human or animal studies; or adverse fetal effects in animal studies, but no available human data. Category D: evidence of fetal risk, but benefits outweigh risks. Category X: evidence of fetal risk. Risks outweigh any benefits.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

Patient discussion about Corticosteroids

Q. I received a corticosteroid injection in my left knne th A.M. Knee is all stiff & swollen. Is this normal?

A. actually you might have already had an arthritis in your knee before, then your doctor injected you with a corticosteroid into the affected joint. usually you will feel better (less pain) in your affected joint. if the symptoms don't improve then I suggest you to go see your specialist for further advise and treatment.

More discussions about Corticosteroids
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References in periodicals archive ?
Results of our study show that in patients of hand eczema which becomes chronic and difficult to treat, the possibility of ACD to topical corticosteroids should be considered, as they are commonly used to treat hand eczema, Diagnostic patch testing would be an invaluable tool to rule in or rule out ACD and would help in better management of the patients in terms of improving the quality of life.
Studies found that corticosteroids adversely impact the femoral head in a dose-dependent manner [20-22].
What are corticosteroids? Corticosteroids are hormones produced naturally within the adrenal cortex or synthetically.
The benefits of systemic corticosteroids can be substantial, so physicians likely will continue to try them initially in the treatment of severe asthma, Wenzel said.
Hence, the majority (98.22%) of patients did not require repetition of injection therapy, which is a major problem associated with the short-term effect of corticosteroids.2,7,8,11,12 Only 1.78% required repetition of injection once after a duration of 1 year, which is safer as stated before and proposes that effects of this management can be long lasting.
and few other studies have found no significant improvement with physical therapy, and instead they suggested GH intra-articular (IA) corticosteroid injection having much beneficial effects as compared to other form of treatment10-12.
There Is still great variation in approaches to therapy: IVIG, corticosteroids, cyclosporine, biologic agents such as etanercept, supportive care, and debridement.
With respect to pain scores, the researchers found no significant difference between corticosteroids and NSAIDs within seven days of treatment based on moderate-quality evidence from two randomized, controlled trials (RCTs) involving 534 patients (standardized mean difference = -0.09; 95 percent confidence interval, -0.26-0.08).
Patients with skin diseases who were prescribed corticosteroids were included while pregnant and lactating women and patients with psychological disorders were excluded from the study.
Intravitreal corticosteroids may be the only effective treatment for refractory uveitic CME [6].
Clinical data does demonstrate that after having Roactemra plus corticosteroids for one year, more people were able to sustain a remission and require smaller doses of corticosteroids compared with people having corticosteroids alone.

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