corticosteroids


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Related to corticosteroids: prednisone, Topical corticosteroids

Corticosteroids

 

Definition

Corticosteroids are group of natural and synthetic analogues of the hormones secreted by the hypothalamic-anterior pituitary-adrenocortical (HPA) axis, more commonly referred to as the pituitary gland. These include glucocorticoids, which are anti-inflammatory agents with a large number of other functions; mineralocorticoids, which control salt and water balance primarily through action on the kidneys; and corticotropins, which control secretion of hormones by the pituitary gland.

Purpose

Glucocorticoids have multiple effects, and are used for a large number of conditions. They affect glucose utilization, fat metabolism, and bone development, and are potent anti-inflammatory agents. They may be used for replacement of natural hormones in patients with pituitary deficiency (Addison's disease), as well as for a wide number of other conditions including, but not limited to, arthritis, asthma, anemia, various cancers, and skin inflammations. Additional uses include inhibition of nausea and vomiting after chemotherapy, treatment of septic shock, treatment of spinal cord injuries, and treatment of hirisutism (excessive hair growth). The choice of drug will vary with the condition. Cortisone and hydrocortisone, which have both glucocorticoid and mineralocorticoid effects, are the drugs of choice for replacement therapy of natural hormone deficiency. Synthetic compounds, which have greater anti-inflammatory effects and less effect on salt and water balance, are usually preferred for other purposes. These compounds include dexamethasone, which is almost exclusively glucocorticoid in its actions, as well as prednisone, prednisolone, betamethasone, trimacinolone, and others. Glucocorticoids are formulated in oral dosage forms, topical creams and ointments, oral and nasal inhalations, rectal foams, and ear and eye drops.
Mineralocorticoids control the retention of sodium in the kidneys. In mineralocorticoid deficiency, there is excessive loss of sodium through the kidneys, with resulting water loss. Fludrocortisone (Florinef) is the only drug available for treatment of mineralocorticoid deficiency, and is available only in an oral dosage form.
Corticotropin (ACTH, adrenocorticotropic hormone) stimulates the pituitary gland to release cortisone. A deficiency of corticotropic hormone will have the same effects as a deficiency of cortisone. The hormone, which is available under the brand names Acthar and Actrel, is used for diagnostic testing, to determine the cause of a glucocorticoid deficiency, but is rarely used for replacement therapy since direct administration of glucocorticoids may be easier and offers better control over dosages.

Recommended dosage

The dosage of glucocorticoids varies with the drug, route of administration, condition being treated, and patient. Consult specific references.
Fludrocortisone, for use in replacement therapy, is normally dosed at 0.1 mg/day. Some patients require higher doses. It should normally be administered in conjunction with cortisone or hydrocortisone.
ACTH, when used for diagnostic purposes, is given as 10 to 25 units dissolved in 500 ml of 5% dextrose injection infused IV over eight hours. A long-acting form, which may be used for replacement therapy, is given by subcutaneous (SC) or intramuscular (IM) injection at a dose of 40 to 80 units every 24-72 hours.

Precautions

Glucocorticoids

The most significant risk associated with administration of glucocorticoids is suppression of natural corticosteroid secretion. When the hormones are administered, they suppress the secretion of ACTH, which in turn reduces the secretion of the natural hormones. The extent of suppression varies with dose, drug potency, duration of treatment, and individual patient response. While suppression is seen primarily with drugs administered systemically, it can also occur with topical drugs such as creams and ointments, or drugs administered by inhalation. Abrupt cessation of corticosteroids may result in acute adrenal crisis (Addisonian crisis) that is marked by dehydration with severe vomiting and diarrhea, hypotension, and loss of consciousness. Acute adrenal crisis is potentially fatal.
Chronic overdose of glucocorticoids leads to Cushingoid syndrome, which is clinically identical to Cushing's syndrome and differs only in that in Cushingoid the excessive steroids are from drug therapy rather than excessive glandular secretion. Symptoms vary, but most people have upper body obesity, rounded face, increased fat around the neck, and thinning arms and legs. In its later stages, this condition leads to weakening of bones and muscles with rib and spinal column fractures.
The short term adverse effects of corticosteroids are generally mild, and include indigestion, increased appetite, insomnia, and nervousness. There are also a very large number of infrequent adverse reactions, the most significant of which is drug-induced paranoia. Delirium, depression, menstrual irregularity, and increased hair growth are also possible. Consult detailed reviews for further information.
Long-term use of topical glucocorticoids can result in thinning of the skin. Oral steroid inhalations may cause fungal overgrowth in the oral cavity. Patients must be instructed to rinse their mouths carefully after each dose. Corticosteroids are pregnancy category C. The drugs have caused congenital malformations in animal studies, including cleft palate. Breastfeeding should be avoided.

Mineralocorticoids

Because fludrocortisone has glucocorticoid activity as well as mineralocorticoid action, the same hazards and precautions apply to fludrocortisone as to the glucocorticoids. Overdose of fludrocortisone may also cause edema, hypertension and congestive heart failure.
Corticotropin has all the same risks as the glucocorticoids. Prolonged use may cause reduced response to the stimulatory effects of corticotropin.

Warnings and contraindications

Use corticosteroids with caution in patients with the following conditions:
  • osteoporosis or any other bone disease
  • current or past tuberculosis
  • glaucoma or cataracts
  • infections of any type (virus, bacteria, fungus, amoeba)
  • sores in the nose or recent nose surgery (if using nasal spray forms of corticosteroids)
  • underactive or overactive thyroid
  • liver disease
  • stomach or intestine problems
  • diabetes
  • heart disease
  • high blood pressure
  • high cholesterol
  • kidney disease or kidney stones
  • myasthenia gravis
  • systemic lupus erythematosus (SLE)
  • emotional problems
  • skin conditions that cause the skin to be thinner and bruise more easily

Interactions

Corticosteroids have many drug interactions. Consult specific references.

Resources

Organizations

American Academy of Allergy, Asthma and Immunology. 611 East Wells Street, Milwaukee, WI 53202. (414) 272-6071. http://www.aaaai.org.
Asthma and Allergy Foundation of America. 1125 15th Street NW, Suite 502, Washington, DC 20005. (800) 727-8462. http://www.aafa.org.
National Heart, Lung and Blood Institute. National Institutes of Health, P.O. Box 30105, Bethesda, MD 20824-0105. (301) 251-1222. 〈http://www.nhlbi.nih.gov/nhlbi/nhlbi.htm〉.

Key terms

Hallucination — A false or distorted perception of objects, sounds, or events that seems real. Hallucinations usually result from drugs or mental disorders.
Hormone — A substance that is produced in one part of the body, then travels through the bloodstream to another part of the body where it has its effect.
Inflammation — Pain, redness, swelling, and heat that usually develop in response to injury or illness.
Ointment — A thick, spreadable substance that contains medicine and is meant to be used on the outside of the body.
Pregnancy category — A system of classifying drugs according to their established risks for use during pregnancy. Category A: controlled human studies have demonstrated no fetal risk. Category B: animal studies indicate no fetal risk, but no human studies; or adverse effects in animals, but not in well-controlled human studies. Category C: no adequate human or animal studies; or adverse fetal effects in animal studies, but no available human data. Category D: evidence of fetal risk, but benefits outweigh risks. Category X: evidence of fetal risk. Risks outweigh any benefits.

corticosteroids

the glucocorticoid and mineralocorticoid hormones secreted by the adrenal cortex. See also adrenal glands, aldosterone, hormones (table) , steroid hormones.

Patient discussion about corticosteroids

Q. I received a corticosteroid injection in my left knne th A.M. Knee is all stiff & swollen. Is this normal?

A. actually you might have already had an arthritis in your knee before, then your doctor injected you with a corticosteroid into the affected joint. usually you will feel better (less pain) in your affected joint. if the symptoms don't improve then I suggest you to go see your specialist for further advise and treatment.

More discussions about corticosteroids
References in periodicals archive ?
Analyzes the market for corticosteroid drugs delivered via oral inhalers
Future studies should focus on identifying subgroups of patients who may benefit from intranasal or systemic corticosteroid treatment," they concluded.
The patients were randomized to one of four groups: corticosteroid injection, placebo injection, corticosteroid injection plus multimodal physiotherapy, or placebo injection plus multimodal physiotherapy (JAMA 2013;309:461-9).
In 16 patients, a paired analysis was performed before and during high-dose corticosteroid therapy with a median (range) dose of 36.
Intranasal corticosteroids versus oral HI receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials.
Patients should be made aware of the possible side effects of corticosteroids and of alternative treatment options.
procumbens applied intraperitoneally in rats has an inhibitory effect on the acute inflammatory response independent of the activity of adrenal corticosteroids.
Preferred--High-dose inhaled corticosteroid and salmeterol and (if needed) oral corticosteroid.
For more severe disease, the inhaled corticosteroids can be ramped up and supplemented with other medications to control the asthma.
Corticosteroids are used for a wide variety of conditions with the therapeutic goal of reducing inflammation.
Survey questions asked for physician responses concerning medical services provided to the competitive high school and college athlete and the use of short-term oral corticosteroids within the previous 2 years, dosage and duration of treatment, indications for use and efficacy of treatment, and incidence and types of complications.

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