Citation: "Direct lineage reprogramming of postmitotic callosal neurons into corticofugal
neurons in vivo"; Caroline Rouaux & Paola Arlotta; Nature Cell Biology 15, 214-221 (2013), published online 20 January 2013, DOI: 10.1038/neb2660
Corticofugal projection fibers also form axonal projections on the neurons existing in the red nuclei, vestibular nuclei, bulbar ventral reticular nuclei, and the bulbar raphe nuclei of the brainstem, which is considered to be involved in motor control [11-13].
Isa, "Large-scale reorganization of corticofugal fibers after neonatal hemidecortication for functional restoration of forelimb movements," European Journal of Neuroscience, vol.
Li, "Efficient generation of corticofugal
projection neurons from human embryonic stem cells," Scientific Reports, vol.
These increased levels of corticofugal
output, where messages are directed away from the cerebral cortex, may inhibit afferent sensorimotor impulses leading to a diminished awareness of bodily sensation and could account for the manifested sensory deficits and la belle indifference.
Anatomically, this would be certainly possible via corticofugal connections that connect corresponding parts of the tonotopic maps, as documented in animal models [68, 69].
Suga, "Corticofugal amplification of subcortical responses to single tone stimuli in the mustached bat," Journal of Neurophysiology, vol.