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a rare, progressive disease (considered by some a variant of Parkinson disease) involving both cerebral cortex and extrapyramidal structures; clinically manifest as disturbances of voluntary movements and rigidity; pathologic characteristics include degeneration of the cerebral cortex with balloon neurons and degeneration of the substantia nigra; apraxia, cortical sensory loss, myoclonus, and phantom limb syndrome have been reported.
Farlex Partner Medical Dictionary © Farlex 2012
corticobasal degenerationA rare idiopathic cerebrodegenerative “tauopathy” which is difficult to diagnose in vivo (less than 25% are correctly diagnosed), as many patients carry the diagnosis of progressive supranuclear palsy whilst alive. Of those with a clinical diagnosis of corticobasal degeneration in vivo, 75% had another diagnosis at autopsy; again, many had progressive supranuclear palsy.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
cor·ti·co·ba·sal de·gen·er·a·tion(kōr'ti-kō-bā'săl dĕ-jen'ĕr-ā'shŭn)
A rare, progressive disease involving both cerebral cortex and extrapyramidal structures; clinically manifested as disturbances of voluntary movements and rigidity; pathologic characteristics include degeneration of the cerebral cortex with balloon neurons and degeneration of the substantia nigra.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
A neurological disorder in which brain cells atrophy and die in the basal ganglia and the cortex of the brain. The disease produces symptoms similar to those found in Parkinson's disease but does not respond to parkinsonian medications.
See also: degeneration
Medical Dictionary, © 2009 Farlex and Partners