TR4 assessment promises to provide an important new tool in advancing understanding of a range of neurodegenerative diseases such as Progressive Supranuclear Palsy, Corticobasal
Degeneration and other dementias.
The national organization has funded more than 190 research studies regarding PSP and related diseases, corticobasal
degeneration and multiple system atrophy.
Andy Copp, from Keith, was diagnosed with corticobasal
degeneration (CBD) in March 2016, which caused him to suffer from worsening mobility, poor balance and slurred speech.
The PET imaging tracer has the potential to visualise tau pathology in diverse tauopathies, including Mild Cognitive Impairment (MCI), dementia due to Alzheimer's disease (AD), Corticobasal
Degeneration Syndrome (CBS) and Progressive Supranuclear Palsy (PSP).
(1) A general term for a group of neurodegenerative diseases, such as Alzheimer's disease, progressive supranuclear palsy (PSP), corticobasal
degeneration (CBD) and Pick's disease, that show tau protein accumulation in the brain as histopathology
James was eventually diagnosed with corticobasal
degeneration (CBD) - a rare brain condition that currently affects only 100 people in the UK.
Some studies showed that C9orf72 repeats could be found in patients with Parkinson's disease, Alzheimer's disease, progressive supranuclear palsy, and corticobasal
degeneration, in addition to FTLD and ALS (8,18).
(11) In addition, an olfactory test (presenting various odors to the patient for identification) can differentiate PD from progressive supranuclear palsy and corticobasal
degeneration; however, it will not distinguish PD from multiple system atrophy.
Certain nuclei in BG and motor-related cortical areas comprise the corticobasal
ganglia (CBG) motor network , playing an important role in adjusting voluntary movements by inhibiting involuntary movements.
Some genes, such as apolipoprotein E (ApoE) and microtubule-associated protein tau (MAPT), are of particular interest because of their known association with dementia in other neurodegenerative diseases, such as Alzheimer's disease (AD) and atypical parkinsonian syndromes, including progressive supranuclear palsy and corticobasal
degeneration (Morley et al., 2012) .
A recent fMRI study assessed the functional connectivity density (FCD) of dancers during rest and reported functional changes in motor regions, especially within sensorimotor cortices, showing higher resting-state functional connectivity density (rs-FCD) in corticobasal