Neurologic findings include epilepsy due to
cortical dysgenesis, hemiparesis due to unilateral atrophy, mental retardation due to the widespread failure of cerebral blood flow, and migraine-like headache (2).
Hemimegalencephaly, characterized by hamartomatous growth of a cerebral hemisphere, has been categorized under the term of "
cortical dysgenesis" owing to disorders of proliferation.7
Intrauterine-onset myoclonic encephalopathy associated with cerebral
cortical dysgenesis. J Child Neurol 1993;8:164-70.
* The precise neuropathology of
cortical dysgenesis cannot be based on neuroimaging findings; the histologic examination performed in one case revealed a polymicrogyric convolutional pattern.
Microscopic examination of the cerebellum revealed the presence of
cortical dysgenesis. Folia were reduced in size and number and displayed evidence of abnormal development.