cortexolone


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cor·tex·o·lone

(kōr-teks'ō-lōn),
A mineralocorticoid hormone from the adrenal cortex.
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Another investigational topical acne therapy to keep an eye on is cortexolone.
We selected the concentration of cortexolone on the basis of previous studies (Harlow et al.
5 ppb), cortexolone (2 [micro]M), phenytoin plus cortexolone, or [iAs.
2] (1, 2, 5, or 8 [micro]M), phenytoin (100 [micro]M), cortexolone (2 [micro]M), cortexolone plus [iAs.
Embryo Dead Surviving Normal Abnormal Treatment explants embryos embryos [n(%)] [n (%)] group (n) (n) (n) Control 42 1 41 41 0 (100) Vehicle 42 3 39 39 0 (100) Phenytoin 42 10 32 14 18 (56) (44) iAs 42 10 32 13 19 (59) (41) Cortexolone 42 2 40 40 0 (100) Phenytoin 42 8 34 34 0 plus (100) cortexolone iAs plus 42 5 37 37 0 cortexolone (100)
p-values were calculated between exposure groups and control, or between exposure groups with or without cortexolone and are : * p<0.
Cortexolone binds to the GR and leads to an altered conformational form of the GR complex, which is then transported into the nucleus (Kaiser et al.
Their expression levels were muted in the presence of cortexolone, indicating that iAs influences the expression of these genes via the GR pathway.
6 October 2010 - Italy-based drug maker Cosmo Pharmaceuticals (SWF: COPN) announced today positive study results about its chemical entity cortexolone 17alfa-propionate (CB-03-01) for the treatment of androgenetic alopecia, a form of hair loss.
Biological profile of cortexolone 17a-propionate (CB-03-01).
Cortexolone 17a-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris.