coronary angiography

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Related to coronary angiography: Coronary angioplasty

cor·o·nar·y an·gi·og·ra·phy

imaging of the circulation of the myocardium by injection of contrast medium, usually by selective catheterization of each coronary artery, formerly by nonselective injection at the root of the aorta.
Farlex Partner Medical Dictionary © Farlex 2012

coronary angiography

Interventional cardiology A diagnostic technique in which a radiocontrast is injected directly into the coronary arteries, allowing visualization and quantification of stenosis and/or obstruction. See Deferred adjunctive coronary angioplasty, Immediate adjunctive coronary angioplasty, Percutaneous transluminal coronary angioplasty, Primary coronary angioplasty, Rescue coronary angioplasty.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

cor·o·nar·y an·gi·og·ra·phy

(kōr'ŏ-nār-ē an'jē-og'ră-fē)
Imaging of the circulation of the myocardium by injection of contrast medium, usually by selective catheterization of each coronary artery, formerly by injection at the root of the aorta.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
Enlarge picture
CORONARY ANGIOGRAPHY: A. tight stenosis; B. artery reopened with a stent
Enlarge picture
CORONARY ANGIOGRAPHY: A. tight stenosis; B. artery reopened with a stent

coronary angiography

Angiography of the coronary arteries to determine any pathological obstructions to blood flow to the heart muscle. It is used to provide definitive images of the coronary arteries that reveal atherosclerotic blockage to blood flow so that those blockages can be surgically bypassed, opened (with angioplasty or stenting, for example), or treated with medications.


Potential hazards of the procedure include coronary artery dissection, kidney failure resulting from exposure to angiographic contrast, and radiation exposure.
See: illustration
See also: angiography
Medical Dictionary, © 2009 Farlex and Partners

Angiography, Coronary

Synonym/acronym: Angiography of heart, angiocardiography, cardiac angiography, cardiac catheterization, cineangiocardiography, coronary angiography, coronary arteriography.

Common use

To visualize and assess the heart and surrounding structure for abnormalities, defects, aneurysm, and tumors.

Area of application



Intravenous or intra-arterial iodine based.


Angiography allows x-ray visualization of the heart, aorta, inferior vena cava, pulmonary artery and vein, and coronary arteries after injection of contrast medium. Contrast medium is injected through a catheter, which has been inserted into a peripheral vein, usually the femoral or brachial vein, for a right heart catheterization or into an artery, usually the femoral or brachial artery, for a left heart catheterization; through the same catheter cardiac pressures and volumes are recorded. Fluoroscopy is used to guide catheter placement, and angiograms (high-speed x-ray images) provide images of the heart and associated vessels which are displayed on a monitor and are recorded for future viewing and evaluation. Digital subtraction angiography (DSA) is a computerized method of removing undesired structures, like bone, from the surrounding area of interest. A digital image is taken prior to injection of the contrast and then again after the contrast has been injected. By subtracting the preinjection image from the postinjection image a higher-quality, unobstructed image can be created. Patterns of circulation, cardiac output, cardiac functions, and changes in vessel wall appearance can be viewed to help diagnose the presence of vascular abnormalities or lesions. Pulmonary artery abnormalities are seen with right heart views, and coronary artery and thoracic aorta abnormalities are seen with left heart views. Coronary angiography is useful for evaluating cardiovascular disease and various types of cardiac abnormalities.

Coronary angiography, more commonly called cardiac catheterization, is a definitive test for coronary artery disease (CAD). CAD is a condition where the blood vessels to the heart lose their elasticity and become narrowed by atheroslerotic deposits of plaque. Significant blockage is treatable using coronary artery bypass grafting (CABG) surgery. Cardiac catheterization can also be used in conjunction with less invasive interventional alternatives to CABG surgery such as percutaneous transluminal coronary angioplasty (PTCA), with or without placement of stents. PTCA is also known as balloon angioplasty because once the blockage is identified and determined to be treatable, a balloon catheter is used to help correct the problem. The balloon in the catheter is inflated to compress the plaque against the sides of the affected vessel. The balloon may be inflated multiple times and with increasing size to increase the diameter of the vessel’s lumen which restores more normal blood flow. A stent, which is a small mesh tube, may be placed in the affected vessel to keep it open after the angioplasty is completed.

Carotid endarterectomy (CEA) is another procedure that can be combined with coronary angiography and may also be part of the PTCA procedure. CEA is performed to reduce stroke risk. Stroke results from severe stenosis of the carotid arteries and release of plaque emboli that travel to the brain, block circulation, and cause brain tissue death. The CEA procedure involves insertion of an additional, separate catheter to insert a device that removes plaque from the walls of the carotid arteries. The devices commonly used to perform CEA employ very small drills or rotating blades to remove the plaque. Balloon angioplasty, with or without stent placement, usually follows CEA.

Applications of Cardiac Catheterization for Infants and Pediatric Patients Cardiac catheterization is very useful in identification of the type of heart defect, determination of the exact location of the defect, and indications regarding the severity of the defect. Some of the common operable heart defects in infants and children include repairs for ventricular septal defects, atrial septic defects, tetrology of Fallot, valve defects, and arterial switches. Cardiac catheterization can also be used as a palliative procedure prior to arterial switch repair. The catheterization, called a balloon atrial septostomy, is used to create a small hole in the inner wall of the heart between the atria that allows a greater volume of oxygenated blood to enter the circulatory system. The improved quality of circulating blood provides some time for very young patients to gain strength prior to the surgical repair. The hole is closed when the corrective surgery is completed.

This procedure is contraindicated for

  • high alertPatients who are pregnant or suspected of being pregnant, unless the potential benefits of a procedure using radiation far outweigh the risk of radiation exposure to the fetus and mother.
  • high alertConditions associated with adverse reactions to contrast medium (e.g., asthma, food allergies, or allergy to contrast medium). Although patients are still asked specifically if they have a known allergy to iodine or shellfish (shellfish contain high levels of iodine), it has been well established that the reaction is not to iodine; an actual iodine allergy would be very problematic because iodine is required for the production of thyroid hormones. In the case of shellfish the reaction is to a muscle protein called tropomyosin; in the case of iodinated contrast medium the reaction is to the noniodinated part of the contrast molecule. Patients with a known hypersensitivity to the medium may benefit from premedication with corticosteroids and diphenhydramine; the use of nonionic contrast or an alternative noncontrast imaging study, if available, may be considered for patients who have severe asthma or who have experienced moderate to severe reactions to ionic contrast medium.
  • high alertConditions associated with preexisting renal insufficiency (e.g., renal failure, single kidney transplant, nephrectomy, diabetes, multiple myeloma, treatment with aminoglycocides and NSAIDs) because iodinated contrast is nephrotoxic.
  • high alertElderly and compromised patients who are chronically dehydrated before the test because of their risk of contrast-induced renal failure.
  • high alertPatients with pheochromocytoma, because iodinated contrast may cause a hypertensive crisis.
  • high alertPatients with bleeding disorders or receiving anticoagulant therapy because the puncture site may not stop bleeding.


  • Allow infusion of thrombolytic drugs into an occluded coronary
  • Detect narrowing of coronary vessels or abnormalities of the great vessels in patients with angina, syncope, abnormal electrocardiogram, hypercholesteremia with chest pain, and persistent chest pain after revascularization
  • Evaluate cardiac muscle function
  • Evaluate cardiac valvular and septal defects
  • Evaluate disease associated with the aortic arch
  • Evaluate previous cardiac surgery or other interventional procedures
  • Evaluate peripheral artery disease (PAD)
  • Evaluate peripheral vascular disease (PVD)
  • Evaluate ventricular aneurysms
  • Monitor pulmonary pressures and cardiac output
  • Perform angioplasty, perform atherectomy, or place a stent
  • Quantify the severity of atherosclerotic, occlusive coronary artery disease

Potential diagnosis

Normal findings

  • Normal great vessels and coronary arteries
  • Normal Adult Hemodynamic Pressures and Volumes Monitored During Coronary Angiography (Cardiac Catheterization)
    PressuresDescription of What Measured Parameter RepresentsNormal Value
    Arterial blood pressure (also known as routine blood pressure)The pressure in the brachial artery; one of the significant vital signs, it reflects the pressure the heart exerts to pump blood through the circulatory system.Systolic (100–140) mm Hg/diastolic (60–90) mm Hg
    Mean arterial pressureThe average arterial pressure of one cardiac cycle; considered a better indicator of perfusion than routine blood pressure but only obtainable by direct measurement during cardiac catheterization.70–105 mm Hg
    Left ventricular pressuresPeak pressure in the left ventricle during systole/Peak pressure in the left ventricle at the end of diastole; indication of contractility of the heart muscle.Systolic (90–140) mm Hg/diastolic (4–12) mm Hg
    Central venous pressure (right atrial pressure)The right-sided ventricular pressures exerted by the central veins closest to the heart (jugular, subclavian, or femoral); used to estimate blood volume and venous return.2–6 mm Hg
    Pulmonary artery pressureThe pressures in the pulmonary arterySystolic (15–30) mm Hg/diastolic (4–12) mm Hg
    Pulmonary artery wedge pressureThe pressure in the pulmonary vessels; used to provide an estimate of left atrial filling pressure, to provide an estimate of left ventricle pressure during end diastole, and a way to measure ventricular preload.4–12 mm Hg
    Volumes Cardiac outputThe amount of blood pumped out by the ventricle of the heart in 1 min4–8 L/min
    Cardiac indexThe cardiac output adjusted for body surface to provide the index which is a more precise measurement; used to assess the function of the ventricle.2.5–4 L/min/m2
    Arterial oxygen saturationThe concentration of oxygen in the blood.95–100%
    Stroke volumeThe amount of blood pumped by each ventricle with each time it contracts in a heartbeat.60–100 mL/beat
    Stroke volume indexThe stroke volume adjusted for body surface to provide the index which is a more precise measurement.33–57 mL/m2
    End diastolic volume (EDV)The amount of blood in the left ventricle at the end of diastole.100–160 mL
    EDV indexEDV adjusted for body surface to provide the index which is a more precise measurement.50–80 mL/m2
    End systolic volume (ESV)The amount of blood in the left ventricle at the end of systole.50–100 mL
    ESV indexESV adjusted for body surface to provide the index which is a more precise measurement.25–50 mL/m2
    Ejection fractionStroke volume expressed as a percentage of end diastolic volume.65%

Abnormal findings related to

  • Aortic atherosclerosis
  • Aortic dissection
  • Aortitis
  • Aneurysms
  • Cardiomyopathy
  • Congenital anomalies
  • Coronary artery atherosclerosis and degree of obstruction
  • Graft occlusion
  • PAD
  • PVD
  • Pulmonary artery abnormalities
  • Septal defects
  • Trauma causing tears or other disruption
  • Tumors
  • Valvular disease

Critical findings

  • Aneurysm
  • Aortic dissection
  • It is essential that critical findings be communicated immediately to the requesting health-care provider (HCP). A listing of these findings varies among facilities.

  • Timely notification of a critical finding for lab or diagnostic studies is a role expectation of the professional nurse. The notification processes will vary among facilities. Upon receipt of the critical finding the information should be read back to the caller to verify accuracy. Most policies require immediate notification of the primary HCP, hospitalist, or on-call HCP. Reported information includes the patient’s name, unique identifiers, critical finding, name of the person giving the report, and name of the person receiving the report. Documentation of notification should be made in the medical record with the name of the HCP notified, time and date of notification, and any orders received. Any delay in a timely report of a critical finding may require completion of a notification form with review by Risk Management.

Interfering factors

  • Factors that may impair clear imaging

    • Gas or feces in the gastrointestinal tract resulting from inadequate cleansing or failure to restrict food intake before the study.
    • Retained barium from a previous radiological procedure.
    • Metallic objects within the examination field (e.g., jewelry, body rings), which may inhibit organ visualization and can produce unclear images.
    • Inability of the patient to cooperate or remain still during the procedure because of age, significant pain, or mental status.
  • Other considerations

    • Consultation with an HCP should occur before the procedure for radiation safety concerns regarding younger patients or patients who are lactating. Pediatric & Geriatric Imaging Children and geriatric patients are at risk for receiving a higher radiation dose than necessary if settings are not adjusted for their small size. Pediatric Imaging Information on the Image Gently Campaign can be found at the Alliance for Radiation Safety in Pediatric Imaging (
    • Risks associated with radiation overexposure can result from frequent x-ray procedures. Personnel in the room with the patient should wear a protective lead apron, stand behind a shield, or leave the area while the examination is being done. Personnel working in the examination area should wear badges to record their level of radiation exposure.
    • Failure to follow dietary restrictions and other pretesting preparations may cause the procedure to be canceled or repeated.

Nursing Implications and Procedure


  • Positively identify the patient using at least two unique identifiers before providing care, treatment, or services.
  • Patient Teaching: Inform the patient this procedure can assist with assessment of cardiac function and check for heart disease.
  • Obtain a history of the patient’s complaints or clinical symptoms, including a list of known allergens, especially allergies or sensitivities to latex, anesthetics, contrast medium, or sedatives.
  • Obtain a history of results of the patient’s cardiovascular system, symptoms, and results of previously performed laboratory tests and diagnostic and surgical procedures. Ensure results of coagulation testing are obtained and recorded prior to the procedure; a creatinine level is also needed before contrast medium is to be used.
  • Note any recent procedures that can interfere with test results, including examinations using iodine-based contrast medium or barium. Ensure that barium studies were performed more than 4 days before angiography.
  • Record the date of last menstrual period and determine the possibility of pregnancy in perimenopausal women.
  • Obtain a list of the patient’s current medications, including anticoagulants, aspirin and other salicylates, herbs, nutritional supplements, and nutraceuticals, especially those known to affect coagulation (see Effects of Natural Products on Laboratory Values online at DavisPlus). Such products should be discontinued by medical direction for the appropriate number of days prior to a surgical procedure. Note the last time and dose of medication taken.
  • If iodinated contrast medium is scheduled to be used in patients receiving metformin (Glucophage) for non-insulin-dependent (type 2) diabetes, the drug should be discontinued on the day of the test and continue to be withheld for 48 hr after the test. Iodinated contrast can temporarily impair kidney function and failure to withhold metformin may indirectly result in drug-induced lactic acidosis, a dangerous and sometimes fatal side effect of metformin (related to renal impairment that does not support sufficient excretion of metformin).
  • Review the procedure with the patient. Address concerns about pain and explain that there may be moments of discomfort and some pain experienced during the test. Inform the patient that the procedure is usually performed in a radiology or vascular suite by an HCP and takes approximately 30 to 60 min.
  • Sensitivity to social and cultural issues, as well as concern for modesty, is important in providing psychological support before, during, and after the procedure.
  • Explain that an IV line may be inserted to allow infusion of IV fluids such as normal saline, anesthetics, sedatives, or emergency medications. Explain that the contrast medium will be injected, by catheter, at a separate site from the IV line.
  • Inform the patient that a burning and flushing sensation may be felt throughout the body during injection of the contrast medium. After injection of the contrast medium, the patient may experience an urge to cough, flushing, nausea, or a salty or metallic taste.
  • Instruct the patient to remove jewelry and other metallic objects from the area to be examined.
  • Instruct the patient to fast and restrict fluids for 2 to 4 hr prior to the procedure. Protocols may vary among facilities.
  • This procedure may be terminated if chest pain, severe cardiac arrhythmias, or signs of a cerebrovascular accident occur.
  • Make sure a written and informed consent has been signed prior to the procedure and before administering any medications.


  • Potential complications:
  • Establishing an IV site and injection of contrast medium by catheter are invasive procedures. Complications are rare but do include risk for: allergic reaction (related to contrast reaction); bleeding from the puncture site (related to a bleeding disorder, or the effects of natural products and medications known to act as blood thinners—postprocedural bleeding from the site is rare because at the conclusion of the procedure a resorbable device, composed of non-latex-containing arterial anchor, collagen plug, and suture, is deployed to seal the puncture site); blood clot formation (related to thrombus formation on the tip of the catheter sheath surface or in the lumen of the catheter—the use of a heparinized saline flush during the procedure decreases the risk of emboli); hematoma (related to blood leakage into the tissue following needle insertion); infection (which might occur if bacteria from the skin surface is introduced at the puncture site); tissue damage (related to extravasation of the contrast during injection); or nerve injury or damage to a nearby organ (which might occur if the catheter strikes a nerve or perforates an organ).

  • Observe standard precautions, and follow the general guidelines in Patient Preparation and Specimen Collection. Positively identify the patient.
  • Ensure the patient has complied with dietary and fluid restrictions for 2 to 4 hr prior to the procedure.
  • Ensure that the patient has removed external metallic objects from the area to be examined prior to the procedure.
  • Administer ordered prophylactic steroids or antihistamines before the procedure. Use nonionic contrast medium for the procedure if the patient has a history of allergic reactions to any substance or drug.
  • Avoid the use of equipment containing latex if the patient has a history of allergic reaction to latex.
  • Have emergency equipment readily available.
  • Instruct the patient to void prior to the procedure and to change into the gown, robe, and foot coverings provided.
  • Instruct the patient to cooperate fully and to follow directions. Instruct the patient to remain still throughout the procedure because movement produces unreliable results.
  • Record baseline vital signs, and continue to monitor throughout the procedure. Protocols may vary among facilities.
  • Establish an IV fluid line for the injection of saline, sedatives, or emergency medications.
  • Administer an antianxiety agent, as ordered, if the patient has claustrophobia. Administer a sedative to a child or to an uncooperative adult, as ordered.
  • Place electrocardiographic electrodes on the patient for cardiac monitoring. Establish a baseline rhythm; determine if the patient has ventricular arrhythmias.
  • Using a pen, mark the site of the patient’s peripheral pulses before angiography; this allows for quicker and more consistent assessment of the pulses after the procedure.
  • Place the patient in the supine position on an examination table. Cleanse the selected area, and cover with a sterile drape.
  • A local anesthetic is injected at the site, and a small incision is made or a needle is inserted under fluoroscopy.
  • The contrast medium is injected, and a rapid series of images is taken during and after the filling of the vessels to be examined. Delayed images may be taken to examine the vessels after a time and to monitor the venous phase of the procedure.
  • Instruct the patient to inhale deeply and hold his or her breath while the x-ray images are taken, and then to exhale after the images are taken.
  • Instruct the patient to take slow, deep breaths if nausea occurs during the procedure.
  • Monitor the patient for complications related to the procedure (e.g., allergic reaction, anaphylaxis, bronchospasm).
  • The needle or catheter is removed, and a pressure dressing is applied over the puncture site.
  • Observe/assess the needle/catheter insertion site for bleeding, inflammation, or hematoma formation.


  • Inform the patient that a report of the results will be made available to the requesting HCP, who will discuss the results with the patient.
  • Instruct the patient to resume usual diet, fluids, medications, or activity as directed by the HCP. Renal function should be assessed before metformin is resumed.
  • Monitor vital signs and neurological status every 15 min for 1 hr, then every 2 hr for 4 hr, and then as ordered by the HCP. Take temperature every 4 hr for 24 hr. Monitor intake and output at least every 8 hr. Compare with baseline values. Protocols may vary from facility to facility.
  • Observe for delayed allergic reactions, such as rash, urticaria, tachycardia, hyperpnea, hypertension, palpitations, nausea, or vomiting.
  • Instruct the patient to immediately report symptoms such as fast heart rate, difficulty breathing, skin rash, itching, chest pain, persistent right shoulder pain, or abdominal pain. Immediately report symptoms to the appropriate HCP.
  • Assess extremities for signs of ischemia or absence of distal pulse caused by a catheter-induced thrombus.
  • Observe/assess the needle/catheter insertion site for bleeding, inflammation, or hematoma formation.
  • Instruct the patient in the care and assessment of the site and to observe for bleeding, hematoma formation, bile leakage, and inflammation. Any pleuritic pain, persistent right shoulder pain, or abdominal pain should be reported to the appropriate HCP.
  • Instruct the patient to apply cold compresses to the puncture site as needed, to reduce discomfort or edema.
  • Instruct the patient to maintain bedrest for 4 to 6 hr after the procedure or as ordered.
  • Nutritional Considerations: Nutritional therapy is recommended for the patient identified to be at risk for developing CAD or for individuals who have specific risk factors and/or existing medical conditions (e.g., elevated LDL cholesterol levels, other lipid disorders, insulin-dependent diabetes, insulin resistance, or metabolic syndrome). Other changeable risk factors warranting patient education include strategies to encourage patients, especially those who are overweight and with high blood pressure, to safely decrease sodium intake, achieve a normal weight, ensure regular participation of moderate aerobic physical activity three to four times per week, eliminate tobacco use, and adhere to a heart-healthy diet. If triglycerides also are elevated, the patient should be advised to eliminate or reduce alcohol. The 2013 Guideline on Lifestyle Management to Reduce Cardiovascular Risk published by the ACC and AHA in conjunction with the NHLBI recommends a “Mediterranean”-style diet rather than a low-fat diet. The new guideline emphasizes inclusion of vegetables, whole grains, fruits, low-fat dairy, nuts, legumes, and nontropical vegetable oils (e.g., olive, canola, peanut, sunflower, flaxseed) along with fish and lean poultry. A similar dietary pattern known as the DASH diet makes additional recommendations for the reduction of dietary sodium. Both dietary styles emphasize a reduction in consumption of red meats, which are high in saturated fats and cholesterol, and other foods containing sugar, saturated fats, trans fats, and sodium.
  • Recognize anxiety related to test results. Discuss the implications of abnormal test results on the patient’s lifestyle. Provide teaching and information regarding the clinical implications of the test results, as appropriate. Provide contact information, if desired, for the American Heart Association (, the National Heart, Lung, and Blood Institute (, and the Legs for Life (
  • Reinforce information given by the patient’s HCP regarding further testing, treatment, or referral to another HCP. Answer any questions or address any concerns voiced by the patient or family.
  • Instruct the patient in the use of any ordered medications. Explain the importance of adhering to the therapy regimen. As appropriate, instruct the patient in significant side effects and systemic reactions associated with the prescribed medication. Encourage him or her to review corresponding literature provided by a pharmacist.
  • Depending on the results of this procedure, additional testing may be needed to evaluate or monitor progression of the disease process and determine the need for a change in therapy. Evaluate test results in relation to the patient’s symptoms and other tests performed.

Related Monographs

  • Related tests include angiography carotid, blood pool imaging, BNP, BUN, chest x-ray, cholesterol HDL and LDL, cholesterol total, CT abdomen, CT angiography, CT biliary tract and liver, CT cardiac scoring, CT spleen, CT thoracic, CK, creatinine, CRP, electrocardiography, electrocardiography transesophageal, Holter monitor, homocysteine, lipoprotein electrophoresis, MR angiography, MRI abdomen, MRI chest, myocardial perfusion heart scan, plethysmography, aPTT, PT/INR, triglycerides, troponin, and US arterial Doppler carotid.
  • Refer to the Cardiovascular System table at the end of the book for related tests by body system.
Handbook of Laboratory and Diagnostic Tests, © 2013 Farlex and Partners
References in periodicals archive ?
To determine the safety and success of transradial coronary angiography and angioplasty-a local experience.
As coronary angiography is an invasive procedure and the patients who were not symptomatic should not be urged to go for the angiography.
Inspite of these limitation the study clearly provided an idea not to use verapamil with nitrate at the time of coronary angiography but in case of long spasm treatment, it may be a treatment choice.
The diagnosis is made by coronary angiography viewing a type 1 SCAD: a typical aspect of a double lumen with an intimal radiolucent flap [11].
Caption: Figure 2: CT angiography and coronary angiography showing a long and trifurcated left main coronary artery with a prepulmonic course.
Despite its numerous benefits for patients, coronary angiography is also an invasive technique that brings about a lot of physical and psychological problems due to its aggressive nature.
This broad range is due to the different methods to diagnose ischemic heart disease but in this study we used gold standard method by coronary angiography; thus our result are as close to the real prevalence of ischemic heart disease in chronic conduction disorder.
Together with the advances in computer technology and if the images were obtained with appropriate procedures, multi-slice computed tomography (MSCT) coronary angiography could detect coronary artery pathologies with high sensitivity (2).
Coronary angiography in patients with relatively advanced liver disease is more likely to increase the risk of vascular complications, such as bleeding, due to coagulation abnormalities secondary to thrombocytopenia and prolonged prothrombin time [46].
An OCA was defined as presence of a lesion with 100% stenosis or thrombolysis in myocardial infarction (TIMI) flow grade 0 to 1 in one or more major coronary vessels on invasive coronary angiography. Major branch occlusion was incorporated in the major vessel territory.
As a mural thrombus often goes undetected by coronary angiography, intravascular imaging may be recommended in HTx patients with myocardial infarction or suspected coronary spasms.
His retrospective, population-based cohort study of patients in the Western Denmark Heart Registry who were referred for diagnostic coronary angiography during 2003-2012 included nearly 40,000 individuals with stable angina pectoris who were found on elective coronary angiography to have no obstructive CAD, meaning no lesions involving 50% or greater luminal narrowing.