Histopathology showed epidermal acanthosis, deep epidermal invagination of a parakeratotic column (cornoid lamella
), which is distinctive feature of PEODDN with absent granular layer .
Porokeratosis (PK) is an uncommon disorder of epidermal keratinization characterized by the appearance of one or more atrophic patches surrounded by a unique ridge-like border, histologically termed a cornoid lamella
The histological marker is represented by the cornoid lamella
Skin biopsy showed column of parakeratosis suggestive of Cornoid lamella
and focal loss of granular layer beneath the porokeratotic column.
Biopsy of this area showed a cornoid lamella
, which is seen in porokeratosis.
Histology of the lesion showed keratin-filled epidermal invagination with parakeratotic columns of keratinocytes denoting cornoid lamella
. Beneath it, the epidermis displayed vacuolization compatible with the diagnosis of porokeratosis (Figure 2).
Porokeratosis, porokeratosis palmaris et plantaris disseminata, cornoid lamella
INTRODUCTION: Porokeratosis is an autosomal dominant genodermatosis with variable penetrance, characterized by a clonal disorder of keratinization with one or more atrophic patches surrounded by a clinically and histologically distinctive hyperkeratotic ridge like border called the cornoid lamella
. Multiple clinical variants of porokeratosis are recognized.
Key words: Ala nasi, cornoid lamella
, finger, parakeratosis, porokeratosis.
, a histopathological marker, results from abnormal proliferation of keratinocytes.
Porokeratosis is a disorder of keratinization characterized by one or more atrophic macules or patches surrounded by a distinctive hyperkeratotic ridge-like border called a cornoid lamella
. Multiple clinical variants of porokeratosis exist e.g.
Rising from the center of this invagination was a column of dyskeratotic and parakeratotic cells (cornoid lamella