While doing research at the University of Toronto, we hypothesized that cerumen impaction is not a result of overproduction in the ceruminous glands, but a failure of individual corneocytes
in the stratum corneum to separate.
In essence, most products work on the principle of trapping or concentrating water content within the epidermis, replenishing corneocytes
with water, causing them to swell (6) (improving their apposition) and replacing depleted NMFs to improve waterproofing and restore the skin barrier function to the epidermis.
The absence of sufficient quantities of filaggrin results in a defect in corneocyte
hydration and a severe dry skin abnormality.
Using modern confocal microscopy and both 2-D and 3-D fluorescence microscopy with corrected values for cellular swelling, it was found that corneocyte
arrangement showed partial column-like alignments, but less than that assumed in earlier structural models.
It has a brick-and-mortar construction; the bricks " or corneocytes
" are made up of organised threads of keratin that can hold large amounts of water, embedded in a mortar consisting of fatty acids and other lipids.
Emollients are used to soften skin and create a smoother appearance by filling in the gaps between the corneocytes
(the cells that make up a majority of the SC).
It consists of protein rich corneocytes
, embedded in a lipid matrix.
3) Desquamation of the stratum corneum also slows throughout life leading to a buildup of corneocytes
Polysorbate 80 is believed to increase the rate of drug release by penetrating into intracellular matrix followed by interaction and binding with keratin filament which causes disruption of the corneocytes
(Liu et al.
1996) Factors affecting the adherence of Malassezia pachdermatis to canine corneocytes
14 Decreased levels of DHT improve the milieu of the pilosebaseus duct, decrease the secretion of sebaceous glands, thus fix keratinization of infundulum region, cohesion and prevent the formation of corneocytes
microcomedo, resulting in a decreased closed and open comedones, and lead to a decrease in AV lesion counts.
It consists of corneocytes
(bricks) which are bound to the lamellar lipid structure (mortar).