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A tree used by Native Americans as antipyretic and laxative, and by Western herbalists as an appetite stimulant, and to treat renal and hepatic disease
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In the second part of experiment, we investigated the impact of orally administered cornelian cherry on dietary-induced hyperlipidemia in rabbits.
Cornelian cherry significantly increased expression of PPAR[alpha] in the liver compared to all other groups, and this effect was independent of the provision of cholesterol rich or standard feed.
The addition of cornelian cherry significantly decreased the MDA level in group CHOL + CM compared to group CHOL, although it was still higher than in group P.
Cornelian cherry significantly reversed the increased serum level of IL-6 caused by the administering of cholesterol (Fig.
Administering both cornelian cherry and simvastatin significantly prevented the formation of atheromatosis in the thoracic aorta.
The most important results of our study are the following: (1) we found loganic acid to be a main iridoid constituent of liophylisate in the European cultivar of the cornelian cherry, (2) oral administering of this lyophylisate significantly decreased triglycerides in serum, diminished the formation of atherosclerotic changes in the aorta, had a protective effect on lipid peroxidation, the redox system, and proinflammatory cytokines in hypercholesterolemic rabbits, (3) The cornelian cherry significantly increased expression of PPAR[alpha] in the liver.
Moreover, we decided to compare the cornelian cherry's effects to simvastatin, though the effects of the cornelian cherry observed in this study were more similar to fibrates, with a significant decrease of triglycerides and only a slightly beneficial effect on cholesterol levels.
In the second part of our experiment, we assessed the in vivo effects of the cornelian cherry in hypercholesterolemic rabbits.
In this study, we found a pronounced increase in PPAR[alpha] protein expression in the liver of cornelian cherry supplemented rabbits.
We show a marked decrease in MDA and an increase in glutathione concentrations in the livers of either cornelian cherry or simvastatin-treated rabbits.
Once a cornelian cherry leafs up it is covered in roughly oval dark green leaves.
Like the Arnold Promise witch hazel, an ice or snow storm, frigid winds or other (typical) New England spring weather enhances the blooming display of the Cornelian Cherry rather than damages it.