Angiogenesis is undesirable in the cornea because the newly formed blood vessels result in not only the loss of corneal transparency
but also the loss of immunological privilege of the cornea.
The transplantation of CECs in these primates also achieved the recovery of long-term corneal transparency
with a monolayer of hexagonal cells, suggesting that cell adhesion modified by ROCK inhibitor may be an effective treatment for human corneal endothelial disorders.
Exposure keratitis (as assessed clinically by observation for the reduction in corneal transparency
at the exposed part of the cornea) cleared in 16 out of 27 eyes (60%).
We aimed in the current study to evaluate corneal transparency
and visual acuity following ACXL in pediatric keratoconus in a highly populated region with rapidly progressive keratoconus, south KSA (Kingdom of Saudi Arabia).
Corneal epithelium integrity is essential for corneal transparency
Only the introduction of the hypertonic solution therapy induced the improvement of visual acuity, so we hypothesize the crucial influence of pharmacological therapy to restore corneal transparency
. Furthermore, in literature there are four more cases described of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) due to bullous keratopathy after anterior-posterior radial keratotomy (APRK) as an effective surgical option .
of corneal transparency
was constant post-operative complication in Gr-I and similar observations were also recorded by Tyagi et al.
Vessels advancing into the cornea cause corneal inflammation, scarring, edema and lipid accumulation, which can lead to reduction in corneal transparency
and impaired vision; therefore, the treatment of these patients is very important.
To our knowledge, this is the first paper investigating the effects of bone marrow MSCs (BM-MSCs), adipose tissue MSCs (Ad-MSCs), or corneal limbal epithelial stem cells (LSCs) on the antioxidant protective mechanism in the regenerated corneal epithelium and on corneal optical properties evaluated by central corneal thickness (taken as an index of corneal hydration) and corneal transparency
. We found that in contrast to the effect of nanofibers alone (MSCs-free), where profound enzymatic antioxidant/prooxidant imbalance was found in the corneal epithelium, after the treatment of injured corneas with BM-MSCs nanofibers or LSCs nanofibers (less after Ad-MSCs nanofibers), the enzymatic antioxidant protective mechanism was restored in the regenerated corneal epithelium.
The endothelium is a single layer of juxtaposed cuboidal cells with pale and granular cytoplasm, which act in the transport of fluids and maintenance of corneal transparency
(SAMUELSON, 2007; RODRIGUES, 1999; GALERA et al., 2009).
Corneal Endothelial Examination: Corneal endothelium is the primary layer responsible for maintaining the corneal transparency
and tugor hence assessment of this layer forms a crucial step in determining the corneal graft survival.
For example, UCB-MSCs have been transplanted into corneas of mice leading to improved corneal transparency
and increased stromal thickness , and autologous bone marrow MSCs have been used to replace corneal endothelium of rabbits in vivo .