After 3 months postoperatively, the rabbits were sacrificed for the immunohistochemical staining study for corneal epithelial marker keratin 3 (K3), corneal keratocyte
marker vimentin and conjunctival epithelial marker MUC5AC.
Guthoff, "Fluorescence microscopy and three-dimensional imaging of the porcine corneal keratocyte
network," Graefe's Arch.
Funderburgh et al., "Differentiation of human embryonic stem cells into cells with corneal keratocyte phenotype," PLoS ONE, vol.
It is known that both corneal keratocytes and CECs are derived from NCSCs [3, 4, 56].
Hopkinson, "Corneal keratocyte
transition to mesenchymal stem cell phenotype and reversal using serum-free medium supplemented with FGF-2, TGF-ss3 and retinoic acid," Journal of Tissue Engineering and Regenerative Medicine, 2017.
Cornea was examined for anterior thinning, the presence of inflammatory cells associated with the lenticule, and activation of corneal keratocytes
, which may indicate the development of fibrosis [21,22].
Funderburgh, "PAX6 expression identifies progenitor cells for corneal keratocytes
," The FASEB Journal, vol.
Jham et al., "Expression of CD34 and L-selectin on human corneal keratocytes
," Investigative Ophthalmology and Visual Science, vol.
are activated and transformed into myofibroblasts and fibroblasts upon injury, which is an important biological event during corneal wound repair with scar formation .
Effect of MT1-MMP deficiency and overexpression in corneal keratocytes
on vascular endothelial cell migration and proliferation.
Effects of antifungal drugs and delivery vehicles on morphology and proliferation of equine corneal keratocytes
It has been demonstrated that human BM-MSCs can differentiate into epithelial corneal cells in vivo and into corneal keratocytes
in vitro and AT-MSCs can differentiate into epithelial corneal cells in vitro, while human U-MSCs can differentiate into corneal keratocytes
in vivo [66-68].