BPA can disturb thyroid hormone function by reducing T3 binding to the nuclear thyroid receptors (TRs) and recruited nuclear corepressors
(N-CoRs) to the IRs, resulting in transcriptional inhibition.
CtBP family proteins: More than transcriptional corepressors
Unliganded hPXR was able to interact with the corepressors
nuclear receptor corepressor
(NCoR) and silencing mediator of retinoid and thyroid hormone (SMRT; Figure IF).
The researchers say their results are a milestone in our understanding of certain fundamental mechanisms of living organisms, in particular the little-studied role of corepressors
Two well-characterized AR corepressors
are NCoR (nuclear receptor corepressor
) and its homolog SMRT (silencing mediator for retinoid and thyroid hormone receptors) (39).
Nuclear receptors: coactivators, corepressors
and chromatin remodeling in the control of transcription.
DNA hypermethylation plays an important role in gene regulation in relation to the binding of methylcytosine-binding proteins and the recruitment of histone deacetylase and corepressors
Certain cells may produce coactivators or corepressors
that are able to bind to these abnormally shaped receptor complexes, and other cells may not.
Len Freedman, well-known for his work with the Memorial Sloan-Kettering Cancer Center and now with Merck, along with presentations on new research for coactivators and corepressors
, and identification of orphan receptor ligands.
In 1997, O'Malley and his colleagues at Baylor showed that the relative levels of coactivators and corepressors
could reduce or strengthen the effects of tamoxifen in different cells.
These results indicate that PBDEs do not recruit corepressors
Within this context, it will be interesting to learn whether genes encoding the ER, its coactivators, or its corepressors
(106),as well as antiestrogen resistance genes (107) and their variants, will affect the response to tamoxifen.