corepressor


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Related to corepressor: inducer, coactivator

corepressor

 [ko″re-pres´ser]
a small molecule that combines with a protein aporepressor molecule to form an active substance, which then binds to an operator gene and inhibits the synthesis of an enzyme.

co·re·pres·sor

(kō'rē-pres'ŏr),
A molecule, usually a product of a specific metabolic pathway (for example, nuclear protein), which combines with and activates a repressor produced by a regulator gene. The activated repressor then attaches to an operator gene site and inhibits activity of the structural genes. This homeostatic mechanism negatively regulates enzyme production in repressible enzyme systems.

corepressor

(kō′rĭ-prĕs′ər)
n.
A substance that combines with and activates a genetic repressor, thus preventing gene transcription and inhibiting protein synthesis.

co·re·pres·sor

(kō'rĕ-pres'ŏr)
A molecule, usually a product of a specific metabolic pathway, which combines with and activates a repressor produced by a regulator gene. The repressor then attaches to an operator gene site and inhibits activity of the structural genes. This homeostatic mechanism regulates enzyme production in repressible enzyme systems.

corepressor

a substance of low molecular weight which unites with an APOREPRESSOR and reduces the activity of particular structural genes (see OPERON MODEL).
References in periodicals archive ?
Bardwell, "BCoR, a novel corepressor involved in BCL-6 repression," Genes & Development, vol.
During unstimulated conditions, the heterodimer complex is associated with corepressors (NCoR and SMRT), which suppress gene transcription [26].
More recently, a new subtype of Ewing-like sarcomas has been defined by the fusion of the BCOR (BCL6 corepressor) and CCNB3 genes, which are nonadjacent genes on the X chromosome.
CTBP2, a member of the CTBP family, acts as a transcriptional corepressor to modulate cancer cell growth and tumorigenesis by interacting with the C-terminus of the adenoviral E1A oncoprotein [26].
PPARs form heterodimers with the 9-cis-retinoic acid receptor (RXR), which has high affinity for many transcriptional corepressors. The binding of the complex with long-chain fatty acids or eicosanoid-derived products induces a conformational change that permits the replacement of the corepressor with a coactivator.
Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen.
Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1.
A recent study indicated that SIRT6 acts specifically in these processes as a corepressor of hypoxia-inducible factor 1-alpha (HIF1a) and MYC targets via both H3K9 and H3K56 deacetylation (Sebastian et al.
Cytosine methylation of promoter sites is associated with recruitment of corepressor complexes and reduced gene expression [28].
Binding of Rasd1 to NonO modulates NonO's functions by changing NonO from a coactivator to a corepressor of the cAMP dependent pathway which is associated with the repression of a subset of CREB target genes, NR4Al and NR4A2.
Barton, "Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-[beta]-mediated transcription repression," Molecular and Cellular Biology, vol.