corepressor


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Related to corepressor: inducer, coactivator

corepressor

 [ko″re-pres´ser]
a small molecule that combines with a protein aporepressor molecule to form an active substance, which then binds to an operator gene and inhibits the synthesis of an enzyme.

co·re·pres·sor

(kō'rē-pres'ŏr),
A molecule, usually a product of a specific metabolic pathway (for example, nuclear protein), which combines with and activates a repressor produced by a regulator gene. The activated repressor then attaches to an operator gene site and inhibits activity of the structural genes. This homeostatic mechanism negatively regulates enzyme production in repressible enzyme systems.

corepressor

/co·re·pres·sor/ (ko″re-pres´er) in genetic theory, a small molecule that combines with an aporepressor to form the complete repressor.

corepressor

(kō′rĭ-prĕs′ər)
n.
A substance that combines with and activates a genetic repressor, thus preventing gene transcription and inhibiting protein synthesis.

co·re·pres·sor

(kō'rĕ-pres'ŏr)
A molecule, usually a product of a specific metabolic pathway, which combines with and activates a repressor produced by a regulator gene. The repressor then attaches to an operator gene site and inhibits activity of the structural genes. This homeostatic mechanism regulates enzyme production in repressible enzyme systems.

corepressor

a substance of low molecular weight which unites with an APOREPRESSOR and reduces the activity of particular structural genes (see OPERON MODEL).

corepressor

a substance (e.g. the product of a metabolic pathway) that activates a repressor by combining with it.
References in periodicals archive ?
MicroRNAs 10a and 10b are potent inducers of neuroblastoma cell differentiation through targeting of nuclear receptor corepressor 2.
Another protein, called Lxc (formerly called Bof and located within the ImmT region of P1), enhances binding of C1 repressor to certain operator sites along the DNA and is sometimes referred to as a corepressor.
sup][2],[3] AML1 gene is located on the 21[sup]st chromosome and serves as a DNA-binding transcription factor while ETO gene is located on the 8[sup]th chromosome and serves as a corepressor molecular.
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIS-dependent neurogenic gene activation pathway," Cell, vol.
We deduced that DOX and ALOB induced signals that convert NF-[kappa]B from being an activator of gene expression to being a repressor, possibly stimulating the recruitment of corepressor complexes (Campbell et al.
Histone deacetylases (HDACs) 1 and 2 are highly conserved enzymes that help regulate chromatin structure as the core catalytic components of corepressor complexes (Brunmeir et al.
Transcription corepressor CtBP is an NAD+-regulated dehydrogenase.
1997) Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional corepressors, nuclear receptor-corepressor (NCoR) and silencing mediator for retinoic acid receptor and thyroid hormone receptor (SMRT).
The study found that by genetically manipulating the offspring of these species, the researchers were able to suppress the NCoR1 corepressor, which normally acts to inhibit the buildup of muscle tissues.
Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: Coupling protein O-GlcNAcylation to transcriptional repression.