Nuclear proteins that participate in the regulation of transcription of genes that are responsive to ligand-dependent transcription factors. Distinguished loosely into coactivators or corepressors depending on the direction of coregulation. Defective coregulators have been associated with human disease.
See also: coactivator, corepressors.
[co- + regulator]
References in periodicals archive ?
In search for epigenomic modifiers that control adipose tissue function and also impact on T2D pathogenesis, we have recently identified the transcriptional coregulators GPS2 (G-Protein Pathway Suppressor 2) and KDM6B (Histone Lysine Demethylase 6B, also called JMJD3) as strong candidates.
Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting.
The PPARGC1B gene encodes peroxisome proliferator-activated receptor gamma (PPAR[gamma]), coactivator 1 beta (PPARGC1B, or PGC-1[beta]), it belongs to a small family of nuclear receptor coregulators that coordinate responses to metabolic stimuli and stressors (Handschin and Spiegelman, 2006; Lin, 2009).
Finally, AMPK can also regulate p53 [55] and modulates the activity of transcription factors and coregulators that control the cell cycle [56, 57].
macrophylla may contain secondary metabolites that bind ERs or alter coregulators of ERs.
2008; Zhu and Kyprianou 2008), amplification of the AR gene (Koivisto and Helin 1999), changes in the expression of AR coregulators, and mutations of AR itself that enhance its transcriptional activity in response to the binding of ligands such as testosterones (Hull and Bostwick 2008).
Uniqueness of the Environmental Protection Agency Agency and States as Coregulators III.
These coregulators can either enhance (coactivators) or reduce (corepressors) AR transactivation, resulting in altered transcription rates.
Breast cancer endocrine resistance: How growth factor signaling and estrogen receptor coregulators modulate response.
Regulation of these actions is exerted by a number of different coregulators including the coactivators DRIP and SRC, a less well known inhibitor, hairless, and beta-catenin.
Kinase-specific phosphorylation of the oestrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in oestrogen and tamoxifen activity.
Aberrant activation of the androgen receptor (AR) can result from gene amplification, mutation, phosphorylation, activation of coregulators, or androgen-independent activation.