Nuclear proteins that participate in the regulation of transcription of genes that are responsive to ligand-dependent transcription factors. Distinguished loosely into coactivators or corepressors depending on the direction of coregulation. Defective coregulators have been associated with human disease.
See also: coactivator, corepressors.
[co- + regulator]
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex.
Androgen receptor coregulators and their involvement in the development and progression of prostate cancer.
In a previous study at PND 50, BPA treated Sprague-Dawley rats (250 [micro]g/kg) had no change in protein expression of ERa; however, PR-A, which is vital for ductal elongation, and the downstream coregulators SRC-1, SRC-2, and SRC-3, were all significantly increased (Jenkins et al.
When the PPARs proteins bind to a specific ligand, the ligand-binding domains of PPARs will encounter the conformational change followed by promoting the recruitment of nuclear receptor coregulators such as steroid rector coactivator-1 (SRC-1) and eventually influence the transcription of downstream target genes [5].
Greenberg, "Androgen receptor coregulators and their involvement in the development and progression of prostate cancer," International Journal of Cancer, vol.
The phenotypic variation associated with PAX6 mutations may be due to differences in genetic background that affect the expression of PAX6 coregulators and downstream targets.
This major cellular gatekeeper [40] is entangled into the complex gene regulatory network composed of its mediators, effectors, and coregulators [41, 42].
The ultimate biological action could be fine-tuned by modulating specific coregulators, so that the antihyperlipidemic and antihyperglycemic activity is retained without producing the adverse effects of the currently used Rosiglitazone and Pioglitazone.
At the transcriptional level, sequence-specific transcription factors and coregulators work together to orchestrate the transcriptional landscape of stem cells, which determines the on/off state of target genes, thereby controlling the cell fate of stem cells.
Furthermore, daf-16 is involved in posttranslational modifications and interactions with coregulators that constitute important transcriptional regulatory mechanisms [25].
In this case, bgl2 might be subjected to the combined reactions of Xyr1 and several other coregulators.