In search for epigenomic modifiers that control adipose tissue function and also impact on T2D pathogenesis, we have recently identified the transcriptional coregulators
GPS2 (G-Protein Pathway Suppressor 2) and KDM6B (Histone Lysine Demethylase 6B, also called JMJD3) as strong candidates.
in nuclear estrogen receptor action: from concept to therapeutic targeting.
The PPARGC1B gene encodes peroxisome proliferator-activated receptor gamma (PPAR[gamma]), coactivator 1 beta (PPARGC1B, or PGC-1[beta]), it belongs to a small family of nuclear receptor coregulators
that coordinate responses to metabolic stimuli and stressors (Handschin and Spiegelman, 2006; Lin, 2009).
Finally, AMPK can also regulate p53  and modulates the activity of transcription factors and coregulators
that control the cell cycle [56, 57].
macrophylla may contain secondary metabolites that bind ERs or alter coregulators
2008; Zhu and Kyprianou 2008), amplification of the AR gene (Koivisto and Helin 1999), changes in the expression of AR coregulators
, and mutations of AR itself that enhance its transcriptional activity in response to the binding of ligands such as testosterones (Hull and Bostwick 2008).
Uniqueness of the Environmental Protection Agency Agency and States as Coregulators
can either enhance (coactivators) or reduce (corepressors) AR transactivation, resulting in altered transcription rates.
Breast cancer endocrine resistance: How growth factor signaling and estrogen receptor coregulators
Regulation of these actions is exerted by a number of different coregulators
including the coactivators DRIP and SRC, a less well known inhibitor, hairless, and beta-catenin.
Kinase-specific phosphorylation of the oestrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators
associated with alterations in oestrogen and tamoxifen activity.
Aberrant activation of the androgen receptor (AR) can result from gene amplification, mutation, phosphorylation, activation of coregulators
, or androgen-independent activation.