Two distinct CCR5 domains can mediate coreceptor
usage by human immunodeficiency virus type 1.
A) We hypothesize that high levels of immune activation predispose for a coreceptor
Antiretroviral-free remission had previously been achieved in a patient who received an HSCT from a donor with a homozygous 32-base pair deletion in the gene encoding CCR5, a coreceptor
The protein fibroblast growth factor-23 (FGF-23) (5) and its coreceptor
Klotho have attracted great attention in recent years and are currently recognized as playing a key role in the regulation of phosphatemia.
Summary of Study Results In the study, T-cells from HIV subjects were isolated and edited with ZFNs to make them resistant to the virus by knocking out the CCR5 gene which encodes a coreceptor
required for HIV infection.
Neuropilin-1 (NRP-1) was found to be a receptor or coreceptor
for the specific isoform VEGF165 and expressed on endothelial cells (ECs) and several types of tumor cells.
Evidence for a domain-swapped CD4 dimer as the coreceptor
for binding to class II MHC.
The earliest studies exploring heritability of response to ART examined variation in HIV coreceptor
alleles CCR5 and CXCR4.
Normally, this gene encodes the lymphocyte transmembrane coreceptor
to which HIV can bind (Dean et al.
The first link between Wnt signaling and human bone disease came from the observations that inactivating mutations in the Wnt coreceptor
, LRP5, cause the osteoporosis-pseudoglioma syndrome (51).
Alcohol exposure increases the number of cells with the CXCR4 coreceptor
, resulting in enhanced early replication of viral subtypes that use CXCR4 as a coreceptor
(Liu et al.
Activation and coreceptor
expression of T lymphocytes induced by highly active antiretroviral therapy in Chinese HIV/AIDS patients.