coreceptor

co·re·cep·tor

(kō'rē-sep'tōr),
A cell surface receptor, which, when bound to its respective ligand, modulates antigen receptor binding or affects cellular activation after antigen-receptor interactions.

co·re·cep·tor

(kō'rĕ-sep'tŏr)
A cell surface protein that increases the sensitivity of the antigen receptor to antigen by binding to other ligands.

coreceptor

(ko?re-sep'tor) [ com- + receptor]
A structure on a cell membrane that enhances the action of the cell receptor.

CCR5 coreceptor

A cell surface receptor found on macrophages that facilitates entry of HIV-1 into these cells. Chemokines released by T cells attempt to compete with HIV by blocking the receptor to prevent infection.

CXCR4 coreceptor

A cell surface receptor found on T cells that facilitates entry of HIV-1into these cells.
Synonym: fusin
References in periodicals archive ?
Role of CD8[beta] domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus.
Simultaneously the expression of a-klotho, a coreceptor for FGF23, is reduced in the kidney, leading to FGF23 hyporesponsiveness, namely, FGF23 resistance in kidney [4, 5].
The HIV can still replicate but the resulting virions are immature and cannot infect new cells (Figure 2); (iv) fusion inhibitors act by blocking the fusion of HIV envelope with the host CD4 cell membrane, thus preventing the entry of HIV into the CD4 cells; (v) chemokine receptor antagonists (CCR5 Antagonists) act by blocking the CCR5 coreceptor and prevent HIV from entering the cell; (vi) integrase inhibitors work by stopping the virus from integrating with DNA of human cells.
NRP1, although generally considered a coreceptor for these growth factors, has been observed to induce activation of some signaling pathways also independently of other tyrosine kinase receptor expression [25].
The cross talk between insulin and Wnt signalling occurs at the level of coreceptor LRP 5, which has a profound positive effect on insulin signalling in preadipocytes [71].
The first step in the activation of this pathway is the binding of a Wnt ligand from the extracellular environment to two transmembrane proteins: a Frizzled protein (Fz) acting as the receptor and a low-density lipoprotein receptor-related protein 5 or 6 (Lrp5/6) acting as a coreceptor (Figure 2).
Sema3A does not bind directly to plexin and requires neuropilin as a coreceptor [30-32].
DP T cells represent one of the T cell developmental stages within the thymus; however, unlike thymic DP T cells, peripheral DP T cells display varying levels of coreceptor expression, a memory phenotype, and none of the markers typical of recent thymic emigrants [5-7].
Research has shown that soluble klotho can still act as a coreceptor for FGF-23 signaling [25], although it is believed to not be as active as the membrane form.
T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor. Immunity.
evidenced that AmB-induced release of pro-inflammatory cytokines TNF-[alpha] and IL-6 is dependent on expression of TLR2, CD14 coreceptor, and adaptor protein MYD88.
IL-33 signals via a complex composed of ST2, the primary binding receptor, and a coreceptor, IL-1R AcP, leading to MyD88- and IRAK-dependent MAP kinase and NF-[kappa]B activation.