copy number

copy number

  1. the number of copies of a particular PLASMID per CHROMOSOME present in a CELL.
  2. the number of copies of a GENE in the GENOME of an ORGANISM.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
The SMA STAT test detects deletions in the SMN1 gene and assesses copy number of the SMN2 gene, both essential pieces of information for diagnosing and treating SMA.
(1) The new guideline introduces a more rigorous diagnostic approach, compared with the previous ASCO/CAP 2013 recommendations, (2) regarding the HER2 testing algorithm for a subset of ambiguous and difficult cases that may be observed by using a dual-probe in situ hybridization assay, namely (1) low-level HER2 gene amplification defined by HER2/chromosome enumeration probe 17 (CEP17) ratio [greater than or equal to] 2.0 and average copy number < 4.0 per cell, (2) HER2 copy number gain defined by HER2/CEP17 ratio < 2.0 and average copy number [greater than or equal to] 6.0, and (3) equivocal HER2 status characterized by HER2/CEP17 ratio < 2.0 and average copy number [greater than or equal to] 4.0 and < 6.0.
Along with the high throughput of NGS, improved single-nucleotide variant (SNV) detection accuracy, and continuously dropping cost, several recent bioinformatics algorithms have enabled sensitive analytical identification of other types of variants, mainly copy number variants (CNVs), from NGS read depth or coverage data (9-12).
- Milford, Massachusetts-based life sciences company SeraCare Life Sciences has expanded its suite of clinical genomics development, validation, and QC tools with the launch of dedicated copy number variations (CNV) reference materials for NGS assays - Seraseq Breast CNV Mix, and Seraseq Lung and Brain CNV Mix, the company said.
DNA copy number variations (CNVs) are characteristics of a myriad of human malignancies; however, their influence on gene expression has yet to be clarified.
Copy number variation (CNV) is a genetic variant caused by the rearrangement of the genome [5].
DEFA1 and DEFA3, genes that encode HNP1-3, differ by only a single nonsynonymous coding variant within the third exon and are arrayed in a tandem but slightly random pattern of repeats on chromosome 8p23.1, displaying wide-ranging copy number variations (CNVs) [15, 16].
Copy number variations in the PD-L1 gene in KTs from GCs were analyzed.
Genetically, sAA production is mainly determined by the copy number of the sAA gene, AMY1 [26].
In the present study, we aimed to establish the normal reference range of mtDNA copy number in the Chinese population.
The values of copy number for each sample were normalized using RNAase P as a reference control with 2 copies in the human genome.