coproporphyrinogen

coproporphyrinogen

 [kop″ro-por″fĭ-rin´o-jen]
a porphyrinogen formed from uroporphyrinogen. Two isomers exist naturally, types I and III; the latter is a functional intermediate in heme biosynthesis while the former is produced in an abortive side reaction.

por·phy·rin·o·gens

(pōr'fi-rin'ō-jenz),
Intermediates in the biosynthesis of heme, as follows: four porphobilinogens condense to form uroporphyrinogens I and III (giving rise to side products uroporphyrins I and III) that are decarboxylated to form coproporphyrinogens I and III (giving rise to side products coproporphyrins I and III); coproporphyrinogen III is oxidized to protoporphyrinogen III (IX), which is then oxidized to form protoporphyrin III (IX) (this last intermediate adds ferrous iron to yield heme); certain porphyrinogens are elevated in certain porphyrias.

coproporphyrinogen

/cop·ro·por·phy·rin·o·gen/ (-por″fĭ-rin´o-jen) a porphyrinogen (q.v.) formed from uroporphyrinogen and existing naturally as two isomers, types I and III.

coproporphyrinogen

the fully reduced, colorless compound giving rise to coproporphyrin by oxidation.
References in periodicals archive ?
In the second step, coproporphyrinogen III is formed from the synthesized ALA, following four reactions in the cytoplasm (Fig.
J was diagnosed with HCP, a type of porphyria caused by a defect in coproporphyrinogen oxidase that leads to an accumulation of coproporphyrinogen III.
The other 2 acute porphyrias arise from deficiencies later in the pathway: coproporphyrinogen oxidase in hereditary coproporphyria (HCP) and protoporphyrinogen oxidase in variegate porphyria (VP).
Further researches on the characteristics of chlorophyll metabolism indicated that the precursors of D-aminolevulinic acid (ALA), porphobilinogen (PBG), uroporphyrinogen III (Urogen III), coproporphyrinogen III (Coprogen III), protoporphyrin IX (Proto IX), Mg-protoporphyrin IX (Mg-Proto IX) and protochlorophyllide (Pchlide) in chlorophyll biosynthesis in Burley21 were lower than in Maryland609 at vigorous growing period; the activity of D-aminolevulinate dehydratase (ALAD) in Burley21 was 0.
25,30] The inhibitory effect of lead acetate on conversion of coproporphyrinogen III to protoporphyrin IX results in shortening of erythrocyte life span and a decrease in the production of Hb.
In AIP urinary ALA and PBG are markedly elevated, and in VP urinary ALA, PBG and coproporphyrinogen levels are high.
Pb inhibits the three enzymes responsible for heme synthesis; the heme: D-aminolevulinic acid dehydratase (ALAD), the coproporphyrinogen decarboxylase and the ferrochelatase [19].
The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans.
The steps in the heme synthesis pathway that are most vulnerable to heavy metal inhibition are those that involve the enzymes uroporphyrin decarboxylase (UROD) and coproporphyrinogen oxidase (CPOX).
The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans.
Further researches on the characteristics of chlorophyll metabolism indicated that the precursors of d- aminolevulinic acid (ALA), porphobilinogen (PBG), uroporphyrinogen III (Urogen III), coproporphyrinogen III (Coprogen III), protoporphyrin IX (Proto IX), Mg-protoporphyrin IX (Mg-Proto IX) and protochlorophyllide (Pchlide) in chlorophyll biosynthesis in Burley21 were lower than in Maryland609 at vigorous growing period; the activity of d-aminolevulinate dehydratase (ALAD) in Burley21 was 0.
We showed that this probably results from the competitive inhibition of hydroxymethylbilane synthase by coproporphyrinogen and protoporphyrinogen, substrates which accumulate in VP and HCP.