Huie, "Screening of urinary coproporphyrin
using cloud point extraction and chemiluminescence detection," Talanta, vol.
Twenty-four-hour urinary levels of uroporphyrin and coproporphyrin
In porphyrin testing, uroporphyrin is an indicator for aluminum, coproporphyrin
for lead, and precoproporphyrin for mercury.
activity is also increased due to depression of coproporphyrin
Uroporphyrins (UP) 4 ug/L Undefined Uroporph(UP),24hr 11 uq/24 hr 0-24 Heptacarboxyl (7-CP) <1 ug/L Undefined Heptacab(7-CP),24hr <3 ug/24 hr 0-4 Hexacarboxyl (6-CP) <1 jig/L Undefined Haxacarb (6-CP) ,24hr <3 High ug/24 hr 0-1 Pentacarboxyl (5-CP) <1 ugr/L Undefined Pentacarb (5-CP), 24 hr <3 ug/24 hr 0-4 Coproporphyrin
(CP) 16 ug/L Undefined Coproporph (CP) I, 24hr 43 High ug/24 hr 0-24 Coproporphyrin
(CP) III 103 ug/L Undefined Copropor(CP)III,24hr 278 High ug/24 hr 0-74 TESTS LAB Porphyrins, On, 24 Hr Ur.
The patient had elevated levels of total plasma porphyrin, uroporphyrin, and heptacarboxylporphyrin and hexacarboxylporphyrin; she had normal levels of pentacarboxylporphyrin, coproporphyrin
I, and coproporphyrin
1: the effect of icterogenin and rehmannic acid on bile flow and the excretion of bilirubin, phylloerythrin, coproporphyrin
, alkaline phosphatise and bromosulfalein," Proceedings of the Royay Society of London: Series B, Biological Sciences, vol.
Parameters Matrices Value Coproporphyrin
I Urine/24 h 7.65 microg/24h Coproporphyrin
III Urine/24 h 59.3 microg/24h Uroporphyrin Urine/24 h 12.7 microg/24h S-Aminolevulinic Acid Urine/24 h 2.1 mg/24h Porphobilinogen Urine/24 h 1.22 mg/24h N-Acetyl-beta-D-glucosaminidase Urine/24 h 5.14 IU/L [delta]-Aminolevulinic acid dehydratase Blood 75 U/mL Zinc protoporphyrin 67 microg/dL * Reference Parameters normal levels Coproporphyrin
I <25 Coproporphyrin
III <75 Uroporphyrin <25 S-Aminolevulinic Acid 0.25-6.4 Porphobilinogen 0.1-1.7 N-Acetyl-beta-D-glucosaminidase 0.3-12 [delta]-Aminolevulinic acid dehydratase >20 Zinc protoporphyrin <40 * Out of normal levels.
This is related to the overproduction of in-vivo of uroporphyrin, protoporphyrin, coproporphyrin
and their precursors.
It results in an increase in uroporphyrin I and coproporphyrin
I in plasma, red blood cells, urine, feces, and in different tissues.
Tests for detection of porphyrins in the blood, urine and stool were undertaken by the method of Haining et al.2 Presence of uroporphyrin (+++) and coproporphyrin
(+) in the urine was detected by the development of bright red fluorescence under ultraviolet (UV) trans-illuminator, which occurs when concentration of porphyrins is greater than 10 times normal.3 Similarly treated normal urine samples served as controls which showed no fluorescence under UV light.