coproporphyrin

coproporphyrin

 [kop″ro-por´fĭ-rin]
a porphyrin occurring as several isomers; the III isomer, an intermediate in heme biosynthesis, is excreted in the feces and urine in hereditary coproporphyria and variegate porphyria; the I isomer, a side product, is excreted in the feces and urine in congenital erythropoietic porphyria.

cop·ro·por·phy·rin

(kop'rō-pōr'fi-rin),
One of two porphyrin compounds found normally in feces as a decomposition product of bilirubin (hence, from hemoglobin); certain corproporphyrins are elevated in certain porphyrias.
See also: porphyrinogens.

coproporphyrin

/cop·ro·por·phy·rin/ (-por´fĭ-rin) a porphyrin occurring as several isomers; the III isomer, an intermediate in heme biosynthesis, is excreted in the feces and urine in hereditary coproporphyria and variegate porphyria; the I isomer, a side product, is excreted in the feces and urine in congenital erythropoietic porphyria.

coproporphyrin

[kop′rōpôr′firin]
Etymology: Gk, kopros + porphyros, purple
1 any of the nitrogenous organic substances normally excreted in the feces that are products of the breakdown of bilirubin from hemoglobin decomposition.
2 a test used to measure red blood cell porphyrin levels.

cop·ro·por·phy·rin

(kop'rō-pōr'fĭr-in)
One of two porphyrin compounds found normally in feces as a decomposition product of bilirubin (hence, from hemoglobin); certain coproporphyrins are elevated in certain porphyrias.
See also: porphyrinogens

cop·ro·por·phy·rin

(kop'rō-pōr'fĭr-in)
One of two porphyrin compounds found normally in feces as a decomposition product of bilirubin.

coproporphyrin

a porphyrin formed in the blood-forming organs and intestine and found in the urine and feces. There are two chemically distinct substances, coproporphyrins I and III.
References in periodicals archive ?
In porphyrin testing, uroporphyrin is an indicator for aluminum, coproporphyrin for lead, and precoproporphyrin for mercury.
coproporphyrin activity is also increased due to depression of coproporphyrin oxidase enzyme.
Uroporphyrins (UP) 4 ug/L Undefined Uroporph(UP),24hr 11 uq/24 hr 0-24 Heptacarboxyl (7-CP) <1 ug/L Undefined Heptacab(7-CP),24hr <3 ug/24 hr 0-4 Hexacarboxyl (6-CP) <1 jig/L Undefined Haxacarb (6-CP) ,24hr <3 High ug/24 hr 0-1 Pentacarboxyl (5-CP) <1 ugr/L Undefined Pentacarb (5-CP), 24 hr <3 ug/24 hr 0-4 Coproporphyrin (CP) 16 ug/L Undefined Coproporph (CP) I, 24hr 43 High ug/24 hr 0-24 Coproporphyrin (CP) III 103 ug/L Undefined Copropor(CP)III,24hr 278 High ug/24 hr 0-74 TESTS LAB Porphyrins, On, 24 Hr Ur.
Because fecal total porphyrins were moderately increased at 374 nmol/g dry weight (reference value <200 nmol/g) consisting of proto- and coproporphyrin with a trace of uroporphyrin on TLC, a diagnosis of acute intermittent porphyria (AIP) was considered.
This is related to the overproduction of in-vivo of uroporphyrin, protoporphyrin, coproporphyrin and their precursors.
It results in an increase in uroporphyrin I and coproporphyrin I in plasma, red blood cells, urine, feces, and in different tissues.
Determining zinc coproporphyrin in maternal plasma--a new method for diagnosing amniotic fluid embolism.
2 Presence of uroporphyrin (+++) and coproporphyrin (+) in the urine was detected by the development of bright red fluorescence under ultraviolet (UV) trans-illuminator, which occurs when concentration of porphyrins is greater than 10 times normal.
An unexpected new property of tetrapyrroles, including tetramethyl coproporphyrin III, tetrabenzoporphine, copper chlorin e4 ethyl ester, and of carotenoids including zeaxanthin and alpha-cryptoxanthin is their ability to induce mammalian phase 2 proteins that protect cells against oxidants and electrophiles.
6) Abnormal porphyrin metabolism, a characteristic of diseases usually inherited as an enzyme deficiency and resulting in abnormal synthesis of photodynamic agents, including uroporphyrin and coproporphyrin, can result in photosensitization.
Elevated urinary concentrations of coproporphyrin, hexacarboxylporphyrin, and pentacarboxylporphyrin were significantly associated with autism but not with PDD-NOS.