POs, together with tyrosinases, catechol oxidase, and hemocyanin, belong to the type 3 copper protein family, all of which have an active site composed of two histidine-coordinated copper atoms [5, 6].
Although type 3 copper proteins are distributed among almost all organisms, POs are mainly found in arthropods including insects [6,13].
This enzyme belongs to copper protein
containing four ions of metal categorized as three kinds commonly known as T3, T2 and T1.
Laccase is one such copper protein
belonging to the oxidoreductase family that oxidizes a large array of organic substrates i.e phenolic and non-phenolic compounds.
Histaminolytic activity of a copper protein
Adman, on the role of H-bonding in defining blue copper protein
Rios, "Copper and copper proteins
in Parkinson's disease," Oxidative Medicine and Cellular Longevity, vol.
When the level of copper in the hepatocytes is normal or slightly low, Cu [sup]2+ is transported from the cytoplasm into the TGN and binds to blue copper proteins
to form a six domain blue protein, that is, ceruloplasmin, which carries over 95% copper present in the plasm to the various organs.
In addition to general updating, highlights of the sixth edition include: a new section on metal complexes of chlorine, chlorophylls, phthalocyanines, and bacteriochloryphylls; vibrational spectra of novel coordination compounds prepared in inert gas matrices; and vibrational spectra of cytochrome c oxidase and blue copper proteins
. The book is well illustrated and includes extensive references.
The lecture proceeds with a discussion of the various structures of the iron and copper proteins
involved (cytochromes, ferredoxins and plastocyanins) and shows that we currently know rather less about the manganese site implicated in the water-splitting step.
The book is divided into six sections: "Copper in Mammals", "Copper Proteins
", "Copper Transport", "Molecular Pathogenesis of Diseases of Copper Metabolism", "Copper Toxicity and Therapeutics", and "Copper Metabolism and Homeostasis", followed by an extensive index.