cooperativity


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co·op·er·a·tiv·i·ty

(kō-op'er-ă-tiv'i-tē),
A property of certain proteins (often enzymes) in which the binding curves or saturation curves or, in the case of enzymes, a plot of initial rates as a function of initial substrate concentration, are nonhyperbolic; suggests that the binding of a ligand has a different affinity at different ligand concentrations. Both allosterism and hysteresis display cooperativity. Compare: allosterism, hysteresis.

cooperativity

/co·op·er·a·tiv·i·ty/ (ko-op″er-ah-tiv´ĭ-te) the phenomenon of alteration in binding of subsequent ligands upon binding of an initial ligand by an enzyme, receptor, or other molecule with multiple binding sites; the affinity for further binding may be enhanced (positive c.) or decreased (negative c.) .

cooperativity

interaction between some proteins in which the binding of one may increase or decrease binding of the other.
References in periodicals archive ?
01], for PMMA its magnitude lies well below the estimate by the earlier model [12], being now similar to just under 14 structural units of this polymer (quantitatively supporting the reported suggestion of a strong, possibly intramolecular, cooperativity [41] of the basic motions), therefore involving about 1/4 of the typical chain size between entanglements [12, 42].
Cooperativity was measured as the slope of the line in a Hill plot between 25% and 75% oxygen saturation.
Distance constraints between microRNA target sites dictate efficacy and cooperativity.
The seventeen contributions that make up the main body of the text cover cooperativity and synergy in multi-metal supramolecular systems, hierarchically assembled titanium(IV) helicates, suprmolecular hosts and catalysts formed by synergistic molecular assemblies of multinuclear zinc(II) complexes in aqueous solutions, and a wide variety of other related material.
Wnt signal amplification via activity cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.
Epithelialmesenchymal transition and cell cooperativity in metastasis.
They have the functional cooperativity and should be taken as an entity.
The substitution of serine in Hb Austin leads to an increase in oxygen affinity and decrease in cooperativity.
Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail.
Denaturation studies are capable of yielding information about the native state of a protein in terms of its cooperativity, intrinsic stability, and the nature of forces required to maintain its three dimensional structure [1-8].