(redirected from convulsants)
Also found in: Dictionary.


A substance that produces convulsions.
See also: eclamptogenic, epileptogenic.
Farlex Partner Medical Dictionary © Farlex 2012


Causing or producing convulsions.
An agent, such as a drug, that causes convulsions.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


(kŏn-vŭl′sănt) [L. convellere, to pull together]
1. An agent that produces a convulsion.
2. Causing the onset of a convulsion.
Medical Dictionary, © 2009 Farlex and Partners

Patient discussion about convulsant

Q. my friend has convulsions what can i do to make it stop and improve his life quality?

A. what type of convulsions? my best friend is epileptic, but as long as he get's his meds and sleep well- nothing ever happens. i know that as a child all my friend ever wanted was to go to school like everyone else... and to go to school trips without being afraid.

More discussions about convulsant
This content is provided by iMedix and is subject to iMedix Terms. The Questions and Answers are not endorsed or recommended and are made available by patients, not doctors.
References in periodicals archive ?
Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation.
Mapping convulsants' binding to the GABA-A receptor chloride ionophore: a proposed model for channel binding sites.
METHODS AND RESULTS: By screening the affinity of RDX for a number of neurotransmitter receptors, we found that RDX binds exclusively to the picrotoxin convulsant site of the [gamma]-aminobutyric acid type A ([GABA.sub.A]) ionophore.
CONCLUSIONS: These results suggest that binding to the [GABA.sub.A] receptor convulsant site is the primary mechanism of seizure induction by RDX and that reduction of GABAergic inhibitory transmission in the amygdala is involved in the generation of RDX-induced seizures.
Here, we present evidence that RDX binds at the convulsant site of the [gamma]-aminobutyric acid type A ([GABA.sub.A]) receptor (Benarroch 2007; Johnston 2005; Kalueff 2007), causing reduction of [GABA.sub.A] receptor-mediated synaptic transmission and induction of epileptiform activity, as we demonstrate in the amygdala, a seizure-prone structure of the limbic system (Aroniadou-Anderjaska et al.
Key words: Nantenine, Aporphine, Alkaloid, Anticonvulsant activity, Convulsant activity
The convulsant activity previously observed at high doses was also investigated.
(i.p) (a dose previously determined as 100% convulsant).
Fisher's exact test was performed to determine significance of other anticonvulsant and convulsant properties results.
At 7 days postfertilization (dpf), after having undergone completion of brain formation at 5 dpf, zebrafish exhibit behavioral, electro-graphic, and molecular changes to chemical convulsants that would be expected from a rodent seizure model.
p,p '-DDE exposure of zebrafish embryos increases sensitivity of the fish to chemical convulsants. Our previous experiments indicated that this effect was apparent at bath exposure levels as low as 0.3 [micro]M p,p '-DDE (Tiedeken and Ramsdell 2009).
After brain maturation (7 days postfertilization), fish were exposed to a chemical convulsant, either pentylenetetrazole or domoic acid; resulting seizure behavior was then monitored and analyzed for changes, using cameras and behavioral tracking software.