Proximal and distal convoluted tubules
could be easily differentiated in Haematoxylin and Eosin (H and E) stain.
Parietal and visceral walls of the Bowman's capsule, capillaries of the glomeruli, the basement membranes of the proximal and distal convoluted tubules
and the brush borders of the proximal convoluted tubules
exhibited strong positive reaction with PAS technique.
Abbreviations: C, renal corpuscles; D, distal convoluted tubules
; P, proximal convoluted tubules
; S, Bowman's space.
Proximal convoluted tubules
are damaged by the toxic effect of gold particles.
At X40 the proximal convoluted tubules
showed swelling of cells apical blebbing and blunting along with loss of brush border in early cases of cell injury.
Accordingly, proximal convoluted tubules
and vessels were affected in respect of their volume and length.
Results and Conclusions: Main morphological changes were seen in proximal convoluted tubules
and glomeruli (HandE PAS).
In one study, to verify changes in kidneys of fetuses following administration of diluted aspartame in pregnant rats, a significant increase in glomerular volume and the nuclear size of cells in the distal and proximal convoluted tubules
and the collecting duct (Martins & Azoubel, 2006).
Amiloride blocks the epithelial sodium channel in the late distal convoluted tubules
, connecting tubules, and collecting ducts in the kidneys thereby inhibiting sodium reabsorption.
SUMMARY: The objective of this study was the evaluation of aspartame effects on morphometric alterations of the glomerulus, proximal and distal convoluted tubules
and collecting ducts of the rat fetal kidney during organogenesis.
This was achieved by performing an experimental study on rats to determine, utilizing karyometry, morphometric alterations induced in the proximal and distal convoluted tubules
, the collector tubules and the glomeruli of kidneys of fetuses by treating pregnant dams with a single dose of cadmium chloride.
The purpose of this research was to assess the effect of sodium cyclamate in kidneys of rats fetuses considering morphometric changes of glomerulus, proximal and distal convoluted tubules
, and collecting duct.