E: In the early part of the distal convoluted tubule
, a co-transporter molecule reabsorbs sodium and chloride from the tubules.
The granular convoluted tubule
(GCT) cell of rodent submandibular glands.
Diuretics also promote lithium increments, particularly thiazides, which can be explained by their main action in the proximal convoluted tubule
, where lithium absorption is higher.
(a) There was a significant increase of iron deposits represented by the DAB-enhanced Prussian blue staining (brown, indicated by a red arrow) in the proximal convoluted tubule
(PCT) of Hp 2-2 diabetic (DM) sections compared with diabetic Hp 1-1 or with Hp 2-2 nondiabetic (nonDM) sections.
PCT: proximal convoluted tubule
; DCT: distal convoluted tubule
; CCD: cortical collecting duct; Pcap: peritubular capillary; TALH: thick ascending limb of the loop of Henle; MCD: medullary collecting duct; VR: vasa recta; tLH: thin limb of the loop of Henle (n = 5/group).
Jacobson, "Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules
," The Journal ofClinical Investigation, vol.
Estradiol enhances thiazide-sensitive NaCl cotransporter density in the apical plasma membrane of the distal convoluted tubule
in ovariectomized rats.
A sufficient supply of native vitamin D (25(OH) D) in the form of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) is required for its synthesis in the kidney's proximal convoluted tubule
Gitelman's syndrome (GS) is an autosomal recessive inherited defect in the thiazide-sensitive sodium-chloride cotransporter (NCCT) in the distal convoluted tubule
. Defective sodium-chloride absorption at this site causes urinary wasting of sodium, chloride, potassium, and magnesium, resulting in hypokalemic metabolic alkalosis with normal or reduced blood pressure .
However, animals treated with sRAGE before each hypoxia circle seldom displayed extensive features of tubule epithelial swelling and narrowed tubular lumens, without significant changes in distal convoluted tubule
There is cystic dilatation of nephrons involving all segments from the proximal convoluted tubule
to collecting duct due to epithelial hyperplasia leading to redundancy and predisposing to cyst formation.
After uric acid is filtered by the glomerulus, almost all of it is reabsorbed in the proximal convoluted tubule
. This is followed by secretion of uric acid back into the tubules before being reabsorbed again.