controlled trial

controlled trial

Clinical research A clinical study in which one group of participants receives an experimental drug while the other receives either a placebo or an approved–'gold standard' therapy. See Blinding, Double-blinded.
References in periodicals archive ?
The authors conducted a randomised, controlled trial to examine the effects of two behavioural weight-loss interventions in 415 obese patients with at least one cardiovascular risk factor.
Of those, only two meta-analyses, or 7%, reported randomized, controlled trial funding sources, and none reported author-industry ties or employment by the pharmaceutical industry, the investigators found (JAMA 2011;305:1008-17).
The findings stem from the Program on Surgical Control of the Hyperlipidemias (POSCH) randomized controlled trial which kicked off at the University of Minnesota in 1975.
This randomized controlled trial compared very-low-dose transdermal hormone therapy with placebo in healthy postmenopausal women who reported at least 7 moderate to severe hot flushes per day or 50 per week.
The starting point was the spreadsheet for analysis of a pre-post parallel-groups controlled trial (available via an article in Sportscience last year), which already included comparison of the groups in the pretests.
This randomised, controlled trial divided a group of 414 men presenting with urethral discharge to a clinic in Jamaica.
(1) In a randomized controlled trial conducted in Philadelphia, participants in a skills-based STD prevention intervention reported less unprotected sex one year later than did a control group, who received a general health promotion intervention.
In a randomized, controlled trial in Guatemala, use of the product reduced the incidence of diarrhea among intervention households by 24%, or 29% when the treated water was stored in a vessel designed specifically for safe storage (5).
But in 1996, when new laparoscopic and balloon procedures were developed, scientists believed it was time to test these operations in a randomized, controlled trial.
A double-blind controlled trial of enzyme potentiated hyposensitization for the treatment of ulcerative colitis.
In this multicenter randomized controlled trial, the investigators compared 2 dosing regimens of tinidazole with placebo for the treatment of bacterial vaginosis in 235 women at 10 geographically diverse US centers.

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