contiguous gene syndrome


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contiguous gene syndrome

A nonspecific term for any clinical syndrome which is caused by the loss, alteration or mutation of two or more genes that are adjacent to each other on the same chromosome, as occurs in deletion.

Examples
Prader-Willi—microdeletion of 15q11-13; WAGR syndrome—deletion of 11p13.

contiguous gene syndrome

A syndrome featuring a range of apparently unrelated clinical defects that are actually due to deletion of a length of DNA containing adjacent genes the loss of each of which causes a specific defect.
References in periodicals archive ?
Tuberous sclerosis complex with polycystic kidney disease of the adult type: the TSC2/ ADPKD1 contiguous gene syndrome.
Renal disease in adults with TSC2/PKD1 contiguous gene syndrome.