Blockade of constitutively
activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer.
Because the XBP1 intron removed by this splicing is only 26 nucleotide' long, it cannot block translation, and therefore XBP1 precursor mRNA is constitutively
translated to produce pXBP1(U), which functions as a negative regulator of pXBP1(S).
That is why 'the transition from Newton to Einstein centrally involves a succession of relativized constitutively
a priori principles (the Newtonian Laws of Motion in the context of the Principia, in the light principle and the principle of relativity in the context of special relativity, the light principle and the principle of equivalence in the context of general relativity), and the existence of such diverse constitutively
a priori principles, on my view, captures the essence of Kuhnian incommensurability' (713-14).
For evaluation of phosphorylated 4E-BP1, we used an antibody that detects phosphorylation at Thr37/46 because (1) phosphorylation on these residues by mammalian target of rapamycin or other upstream pathways is a prerequisite for subsequent hyperphosphorylation at Thr70 and Ser65 as well as for blocking binding to eIF4-E22 and (2) we showed that mutation at Thr37/46 creates a 4E-BP1 form that is constitutively
functionally active and inhibits tumorigenesis.
Historically, the university has been "the only institution that is constitutively
committed to enlightenment," that is, to bringing the heritage of critical thought to bear on issues of public concern.
If representation is constitutively
inadequate for our experience of the world and of others, as Levinas suggests, at the same time Borges's writing leaves us with the knowledge that there is no such thing as a complete escape from representation (except, perhaps, in psychosis).
Studies performed on monolayers of cultured endothelial cells have revealed that ICAM-1 and, to a lesser extent, VCAM-1 are both constitutively
expressed on these cells [28,29].
10) On Soldati's reading, Brentano introduces the idea of mental phenomena as being constitutively
intentional, necessarily directed onto an object.
This is a problem for Dharmakirti insofar as (a) the exercise of our conceptual capacities--which constitutively
involve normative relations such as (in the words of philosopher John McDowell) "one thing's being warranted or correct in light of another" (4)--do not very readily admit of causal explanation; and (b) the constitutively
non-conceptual (kalpanapodha) character of perception consists, for Dharmakirti, precisely in its being causally describable.
Schestag presents a constitutively
broken word that produces transience, difference, and transformation within seemingly permanent things.
In academic essays on modern Islamic thought, two Islamist academics, Suha Taji-Farouki and Bashir M Nafi, observe: "Rather than being a development within cultural traditions that is internally generated, 20th-century Islamic thought is constitutively
responsive; it is substantially a reaction to extrinsic challenges".
Both molecules are synthesized constitutively
and can be detected in the blood.