connexons


Also found in: Encyclopedia.

con·nex·ons

(kŏ-neks'ŏnz),
Complex protein assemblies that traverse the lipid bilayer of the plasma membrane and form a continuous channel with a pore diameter of approximately 1.5 nm; a pair of connexons from two adjacent cells join to form a gap junction that bridges the 2-4-nm gap between the cells, resulting in both electrical and metabolic couplings; one type of connexons makes up the gap junction in the heart and may coordinate the beating of all muscle cells in one section of the heart.
See also: connexins.

connexons

components of the gap junction spaces between nerve cells; metabolic substances pass between nerve cells via these links.
References in periodicals archive ?
Extracellular loops are highly conserved which consists of three cysteine residues mainly responsible for proper alignment of connexons between adjacent cells (19).
Each connexon comprises six connexins which are assembled in the endoplasmic reticulum or in the Golgi apparatus to form a connexon hemi-channel.
In the present study, we used the two-electrode voltage-clamp recording technique to examine the effects of zinc on the currents mediated by the connexons formed by the endogenous connexin (Cx38) of stage V-VI Xenopus oocytes, and those formed by perch Cx35, a connexin expressed in neurons of the vertebrate retina (11, 12).
To characterize the hemichannel activity of connexons, non-junctional current recordings were obtained from single oocytes with a two-electrode voltage-clamp procedure.
Given that the latter appear to express the [Beta]2-like adrenoceptors associated with luminescence control (Awad and Anctil, 1993, 1994), the likelihood is great that intercellular coupling involving Cx43-related connexons participates in downstream transmission of signals to the photocytes themselves.
Possible ultrastructural substrates of junctions involving connexons
1984), "the failure to observe gap junctions in these groups could merely mean that the junctions are very small, consisting of isolated connexons, or small groups of them.
Each connexon comprises a pairs of Connexin43, 46 and 50 subunits (Santana and Waiswo, 2011; Beyer and Berthoud, 2014).
The connexon is a hexagonal arrangement of six subunits of a protein named connexin (Cx).