GJA8

(redirected from connexin-50)

GJA8

A gene on chromosome 1q21.1 that encodes a calcium and pH-dependent transmembrane connexin protein required for lens growth and maturation of lens-fibre cells. 

Molecular pathology
GJA8 mutations have been linked to zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.
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GJA8 gene code for connexin-50, its expression is exceedingly high in fiber cells, and crucial for maintenance of lens appropriate structure and function (Rong et al., 2002).