GJA1

(redirected from connexin-43)

GJA1

A gene on chromosome 6q21-q23.2 that encodes an alpha chain of the gap junction protein family, or connexins.

Molecular pathology
GJA1 mutations are associated with oculodentodigital dysplasia and cardiac malformations.
References in periodicals archive ?
Hiraishi et al., "Modulation of cardiac connexin-43 by omega-3 fatty acid ethyl-ester supplementation demonstrated in spontaneously diabetic rats," Physiological Research, vol.
Ji, "Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice," Brain, vol.
Extracellular ADP-ribosyl cyclase activity of CD38 leads to generation of cADPR outside the cells that is believed to enter cells via membrane channels formed by CD38 dimers or connexin-43 [10, 11].
Swietach, "Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells," Oncogene, vol.
Expression of connexin 43 was performed using Connexin-43 Polyclonal Antibody (Proteintech, Manchester, UK), diluted 1: 200.
Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium.
Importance of Connexin-43 based gap junction in cirrhosis and acuteon-chronic liver failure.
Our recent studies revealed that DEHP adversely affects the synchronicity of a cardiac cell network by disrupting connexin-43, the main component of cardiac gap junctions (Gillum et al.
Changes in gap junction connexin-43 messenger ribonucleic acid levels associated with rat ovarian follicular development as demonstrated by in situ hybridization.
The increased immunoreactivity for connexin-43 was seen 2 days after mild ischemic injury in the rat hippocampus and striatum (Hossain et al., 1994).
Comments: Protection of connexin-43 in the epidermis was confirmed by the following: monoclonal antibody assay on keratinocyte culture; detection of the expression of messenger RNA specific to connexin-43 (RT-PCR) on a keratinocyte culture and immunolocalization on human skin explants.
Kardami, "The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth," Molecular and Cellular Biochemistry, vol.