Role of autoantibodies in the diagnosis of connective-tissue disease
ILD (CTD-ILD) and interstitial pneumonia with autoimmune features (IPAF).
(2) The finding of distorted capillaries in the nail folds using an ophthalmoscope set at 40+ diopter magnification is the best predictor of an associated connective-tissue disease
. (4) A cold-water challenge to trigger an attack of Raynaud's phenomenon produces inconsistent results and is not recommended.
It found no link between implants and connective-tissue disease
One of Mariann Hopkins's treating physicians testified that, although her diagnosis of mixed connective-tissue disease
did not come until after the implants were put in, she had already displayed symptoms of connective-tissue disease
as early as two years before receiving implants.
Citing a string of medical studies showing no link between breast implants and certain connective-tissue diseases
, FDA Commissioner David Kessler recently told a congressional subcommittee that there is "reasonable assurance" that implants do not cause "traditional connective-tissue disease
However, 2 years ago the Food and Drug Administration triggered a moratorium on the use of these implants when sporadic reports began linking them to connective-tissue disease
and autoimmune disorders.
Physicians have long theorized that Marfan's is a connective-tissue disease
. But until now, they weren't sure which of the many connective-tissue components held the defect.
If it arises early in the course of connective-tissue disease
, screening blood serum for it might offer an early warning of such diseases, prompting physicians to monitor such patients closely, Hefeneider suggests.
The estimated annual incidence varies from 1 per 200,000-500,000 population.[1,2] Association of retroperitoneal fibrosis with other connective-tissue diseases
and reported familial occurrences suggest genetic factors may also play a role. The symptoms and signs associated with retroperitoneal fibrosis are nonspecific, and diagnosis requires a high degree of suspicion.
If no other cause can be found, such as arthritis, other connective-tissue diseases
, or a sluggish thyroid which could also cause fatigue, a diagnosis of ME may be considered.
Risk of connective-tissue diseases
and other disorders after breast implantation.
According to a Mayo Clinic study of 749 implant recipients and 1,498 controls between 1964 and 1991, there is no evidence that the implants cause connective-tissue diseases
and other disorders that many women, loudly supported by the news media, have attributed to them.