Diseases such as too much iron in the body (hemochromatosis), inflammation in various organs in the body (sarcoidosis), abnormal protein build up in the body's organs (amyloidosis) and connective tissue disorders
could cause this condition.
Risk factors present at birth include inherited connective tissue disorders
and cerebral arteriovenous malformation, to name a few.
It addresses aspects of genetics like how genes work, genetic mutations, the causes of genetic disorders, and genetic counseling and testing; the inheritance, symptoms, diagnosis, and treatment of disorders resulting from abnormalities in specific genes, such as blood and clotting disorders, connective tissue disorders
, muscular dystrophy and other neuromuscular disorders, cystic fibrosis, heart rhythm disorders, and hearing and vision disorders; chromosome abnormalities like Down syndrome, fragile X syndrome, and Turner syndrome and their diagnosis and treatment; complex disorders with genetic and environmental components, such as addiction, obesity, mental disorders, heart disease, diabetes, and cancer; genetic research; and information for parents of children with genetic disorders.
Leukocytoclastic vasculitis may be idiopathic or associated with drugs, infections, malignancies, and connective tissue disorders
. Infections linked to causing small vessel vasculitis include streptococcal and staphylococcal infections, tuberculosis, leprosy, hepatitis B, hepatitis C, HIV, and infective endocarditis.
Ehlers-Danlos syndromes (EDS) are a clinically and genetically heterogeneous group of heritable connective tissue disorders
characterized by joint hypermobility (JH), skin hyperextensibility, and tissue fragility (1).
The other serious events included five neurologic disorders (two cases of Guillain-Barre syndrome and one each of Bell's palsy, Bickerstaff encephalitis, and lower-extremity weakness), five musculoskeletal and connective tissue disorders
(three with shoulder pain and two with arm pain), three general disorders and administration site conditions (two cases of fever/chills and one case of cellulitis/bursitis), and one case each of a gastrointestinal disorder (acute diarrhea/gastroenteritis), an injury (a fall), and a skin/subcutaneous tissue disorder (keratosis pilaris rubra), according to the investigators.
In addition to being strongly associated with pSS, anti-Ro antibodies are also associated with other connective tissue disorders
to a lesser extent, including systemic lupus erythematosus (SLE).
Other predisposing conditions were five or more pregnancies, being peripartum, fertility treatment, systemic inflammatory conditions and connective tissue disorders
Mixed connective tissue disease (MCTD) is a rare disease and presents with varied overlapping symptoms of different connective tissue disorders
. Many patients evolve into other connective tissue disorders
with the passage of time.
At least 21.2 per cent had cancer, 11.8 per cent had a spinal disease, 5.6 per cent had joint and bone diseases, 1.9 per cent had connective tissue disorders
, while 1.6 per cent had peripheral vascular disorders.
Other etiologies, such as connective tissue disorders
, should be investigated in younger patients such as ours [5, 6].