conjugative plasmid


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Related to conjugative plasmid: conjugation, R plasmid

plasmid

 [plaz´mid]
an extrachromosomal self-replicating structure found in bacterial cells that carries genes for a variety of functions not essential for cell growth. Plasmids consist of cyclic double-stranded DNA molecules, replicating independently of the chromosomes and transmitting through successive cell divisions genes specifying such functions as antibiotic resistance (R plasmid); conjugation (F plasmid); the production of enzymes, toxins and antigens; and the metabolism of sugars and other organic compounds. Plasmids can be transferred from one cell to another by conjugation and by transduction. Some plasmids may also become integrated into the bacterial chromosome; these are known as episomes.
conjugative plasmid a plasmid that is transferred from one bacterial cell to another during conjugation.
F plasmid a conjugative plasmid found in F+ (male) bacterial cells that leads with high frequency to its transfer and much less often to transfer of the bacterial chromosome. A cell possessing the F plasmid (F+, male) can form a conjugation bridge (F pilus) to a cell lacking the F plasmid (F, female), through which genetic material may pass from one cell to another.
F′ plasmid a hybrid F plasmid that contains also a segment of the host chromosome.
R plasmid a conjugative factor in bacterial cells that promotes resistance to agents such as antibiotics, metal ions, ultraviolet radiation, and bacteriophage.

con·ju·ga·tive plas·mid

a plasmid that can effect its own intercellular transfer by means of conjugation; this transfer is accomplished by a bacterium's being rendered a donor, usually with specialized pili.

con·ju·ga·tive plas·mid

(kon'jŭ-gā-tiv plaz'mid)
A plasmid that can effect its own intercellular transfer by means of conjugation; this transfer is accomplished by a bacterium being rendered a donor, usually with specialized pili.

conjugative plasmid

a self-transmissible PLASMID that carries genes promoting its own transfer by CONJUGATION. In GRAM-NEGATIVE BACTERIA conjugative plasmids contain a set of transfer (tra) genes, encoding the conjugation apparatus including the SEX PILUS and the gene products for processing and transfer of genetic material. Many conjugative plasmids can mediate the transfer of chromosomal genes between bacteria, which may involve a covalent association between the plasmid and chromosome as in Hfr STRAINS or PRIME PLASMIDS. Conjugative plasmids can also effect the transfer of certain NON-CONJUGATIVE PLASMIDS that are resident in the same cell. Compare NON-CONJUGATIVE PLASMID.
References in periodicals archive ?
In contrast, plasmids from the USA and the UK belonged to a different restriction map type (the 'American' type) and appeared to be very different to the 24.5 MDa conjugative plasmid of N.
Thus, conjugative plasmids can be transmitted by two distinct modes: horizontal transmission occurs by conjugation, whereas vertical transmission occurs by host cell division.
(9,11,26,41,45) Nevertheless, it is worth noting that [bla.sub.DHA-1] gene was located on LVPK conjugative plasmid. Linkage of [bla.sub.DHA-1] and qnrB4 genes of similar structures has been described in isolates of K.
CTX-M-14-producing strains show a high level of clonal diversity (11,12); therefore, dissemination has been attributed to conjugative plasmids rather than to clonal expansion of a bacterial host strain (13).
We showed that the emerging clone is multidrug resistant and is characterized by a large conjugative plasmid harboring the Tn1721 transposone and tetA gene, which provides reduced susceptibility to tetracyclines.
Spread and maintenance of conjugative plasmids across bacterial populations have been intensively studied from a theoretical point of view, but data from natural populations are scarce (34,37,38).
The presence of a conjugative plasmid and integrons in this serovar is of clinical importance.
Taylor, "The complete nucleotide sequence of the resistance plasmid R478: defining the backbone components of incompatibility group H conjugative plasmids through comparative genomics," Plasmid, vol.
Conjugative plasmids have recently gained attention as potential targets because of the high frequency of antibiotic resistance arising from conjugation, which can be [10.sup.5] times as frequent as spontaneous chromosomal mutation conferring resistance, and indeed resistance against p-lactams and aminoglycosides has been largely spread by conjugative transfer.
The increasing resistance in enterobacteria could be attributed to the presence of conjugative plasmids carrying resistance genes in the environment (LIEBANA et al.
Co-carriage of PMQR determinants along with ESBL-encoding genes on conjugative plasmids have also been reported by a number of investigators.
Vibrio cholerae O139 multiple-drug resistance mediated by Yersinia pestis pIP1202-like conjugative plasmids. Antimicrob Agents Chemother 2008; 52: 3829-36.