Surgeons should wait at least 6 weeks following conization
or LEEP before performing hysterectomy in order to minimize the likelihood of perioperative complications.
Caption: Figure 4: Stage IB1 squamous cervical carcinoma in a 58-year-old woman with radical hysterectomy (A) T2-weighted axial and (B) sagittal MR images show no gross cancerous lesion of uterine cervix but a tissue defect (arrow) after conization
. At histopathological finding, no residual tumor in uterine cervix was found.
Now, cervical (pre)cancer is usually classified by histologic pathology, but cervical conization
will lead to a high risk of premature delivery and abortion for patients.
It helps in avoiding traumatic diagnostic methods like cervical conization
for minor lesions and at the same time significant lesions are not overlooked.
Zhang et al., "Association between human papillomavirus type 16 E6 and E7 variants with subsequent persistent infection and recurrence of cervical high-grade squamous intraepithelial lesion after conization
," Journal of Medical Virology, vol.
However, the study group in this report includes also patients who performed conization
, simple hysterectomy, or no surgery and moreover, 79% of the patients have the preservation of ovaries in situ.
The inclusion criteria were women who had previous positive HPV test results in the population-based cervical cancer screening program and were scheduled for follow-up between April and July 2015, either due to negative cytology and colposcopy or due to the presence of previous cervical epithelial lesions (including women who were under surveillance following conization
or loop electrosurgical excisional procedure (LEEP)).
(iii) Women who have undergone an invasive procedure in the uterine cervix (conization
, biopsy, etc.) in the last 3 months
Upon receipt of the test results, if high-grade precancerous cells are found, the clinician may treat by cryotherapy, laser ablation, loop excision, or cold-knife conization
Pseudoaneurysm of uterine artery causing intra-abdominal and vaginal bleeding after cervical conization
. Obstet Gynecol Sci 2015;58:256-9.
2009  who investigated the factors associated with HPV persistence after conization
in a similar group (77 patients) and found that preoperative HPV type 16 infection was the only significant independent factor (p = 0.021) for HPV persistence out of age, cytology, punch biopsy histology, HPV viral load, and conization
New biological markers are necessary to more precisely direct diagnosis and treatment of patients with cervical lesions, especially young women which often required cold knife conization
, LETTZ, LEEP, or hysterectomy.