These findings were similar to those of Dobson and Ellis who described such spheroliths to be congophilic
and consistent with amyloid .
Muscle biopsy of the left vastus medialis muscle revealed rimmed vacuoles in muscle fibers with necrosis, regeneration, and congophilic
staining inclusions, consistent with a diagnosis of inclusion body myositis (IBM) (Figures 1 and 2).
Esiri, "Severe cerebral congophilic
angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK," Journal of Neurology, Neurosurgery and Psychiatry, vol.
Welt et al., "Early accumulation of intracellular fibrillar oligomers and late congophilic
amyloid angiopathy in mice expressing the Osaka intra-Abeta APP mutation," Translational Psychiatry, vol.
Morphologic PrP aggregates, congophilic
materials, or thioflavin-positive deposits were not detected in 113LBoPrP-Tg037 mice.
The specimens from the renal pelvis and bladder showed loss of congophilic
staining when treated with potassium permanganate, consistent with AA amyloid.
Amyloid or congophilic
angiopathy is also commonly seen in AD.
Biopsy findings were those of amyloidoma, with amorphous congophilic
deposits and apple green birefringence.
(54-56) In fact, the presence of intracellular infections like Borrelia burgdorferi found in AD are thought by MacDonald (57) to be the primary event in the formation of AD amyloid plaques by forming "congophilic
cores" that attract amyloid materials.
These findings amply support a neuropathologic diagnosis of cerebral congophilic
" staining of fixed tissue and the detection of apple-green birefringence when viewed under polarized light remain essential for the diagnosis of amyloidosis.[1,2] Few other laboratory tests have been used so widely and for such a long period of time.
Hereditary cerebral hemorrhage with amyloidosis--Dutch type: a congophilic
angiopathy: an overview.