The patent offers once-weekly oral administration of selective inhibitors of type 1 and/or type 2 isoforms of steroid 5a-reductase, to patients with nodulocystic and conglobate acne vulgaris.
Elorac president and CEO, Dr Jeffrey Bernstein, said, 'We believe our product has many advantages over existing therapies for nodulocystic or conglobate acne.'
"We propose that the designation "very severe" be reserved for cystic and conglobate
According to the firm, nodulocystic and conglobate
acne are the most severe types of acne vulgaris, affecting around 8 to 10 million patients in the United States and causing substantial functional disability because of scarring.
Global and South African guidelines for the use of systemic isotretinoin are: grade IV (nodulocystic or conglobate
acne); scarring acne; lesser grades of acne not responsive to at least 3 months of oral antibiotics combined with a topical retinoid, or at least 4 cycles of hormonal therapy in females; dysmorphophobic patients; and Gram-negative folliculitis.