congenital virilizing adrenalhyperplasia
con·gen·i·tal vir·il·iz·ing a·dre·nalhy·per·pla·si·a(kŏn-jen'i-tăl vir'i-līz-ing ă-drē'năl hī'pĕr-plā'zē-ă)
Any inborn error of metabolism causing hyperplasia of the cortex of suprarenal gland and overproduction of virilizing hormones. Most forms are due to partial or complete 21-hydroxylase deficiency, leading to increased adrenocorticotropic hormone production by the pituitary, stimulating adrenal growth and function. Clinical features include ambiguous genitalia, virilization, and salt-wasting.
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