congenital toxoplasmosis


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Related to congenital toxoplasmosis: Congenital rubella

con·gen·i·tal tox·o·plas·mo·sis

toxoplasmosis apparently resulting from parasites in an infected mother being transmitted in utero to the fetus, observed as three syndromes: acute: most of the organs contain foci of necrosis in association with fever, jaundice, hydrocephaly, encephalomyelitis, pneumonitis, cutaneous rash, ophthalmic lesions, hepatomegaly, and splenomegaly; subacute: most of the lesions are partly healed or calcified, but those in the brain and eye seem to remain active, inasmuch as chorioretinitis is observed in more than 80% of diseased infants; and chronic: usually not recognized during the newborn period, but chorioretinitis and cerebral lesions may be detected weeks to years later.

congenital toxoplasmosis

A transplacental infection with the protozoan Toxoplasma gondii affecting ±13 of fetuses of ♀ with acute acquired toxoplasmosis, most severe if the infection occurs in 1st trimester; children are often normal at birth, followed by blindness, mental retardation; it may affect the brain, lung, heart, eyes, liver Clinical Hydrocephalus, microcephaly, cerebral calcifications, atrophy, chorioretinitis, uveitis, vitritis, convulsions, hyperbilirubinemia, hepatomegaly Diagnosis PCR of amniotic fluid to detect 35-fold repeat of the B1 gene of T gondii Sensitivity 97%–vs 90% with conventional parasitology Lab IgM immunoassay Management Pyrimethamine, sulfadiazine, leukovorin. See TORCH.

con·gen·i·tal tox·o·plas·mo·sis

(kŏn-jen'i-tăl tok'sō-plaz-mō'sis)
A disease caused by the protozoan parasite Toxoplasma gondii, which is transmitted in utero to the fetus, observed as three syndromes: 1) acute: most of the organs contain foci of necrosis in association with fever, jaundice, hydrocephaly, encephalomyelitis, pneumonitis, rash, ophthalmic lesions, hepatomegaly, and splenomegaly; 2) subacute: most of these lesions are partly healed or calcified, but those in the brain and eye seem to remain active, inasmuch as chorioretinitis is observed in more than 80% of diseased infants; and 3) chronic: usually not recognized during the newborn period, but chorioretinitis and cerebral lesions may be detected weeks to years later.
References in periodicals archive ?
To the Editor: Although congenital toxoplasmosis occurs throughout the United States, little information is available about the rates of diagnosed illness in most of the nation, including California.
The small number of cases makes the rate of diagnosed congenital toxoplasmosis somewhat imprecise; a few missed cases would increase the rate considerably.
Additionally, they noted, congenital toxoplasmosis is more common than many genetic and metabolic diseases, such as phenylketonuria, congenital hypothyroidism, and congenital adrenal hyperplasia, for which mandatory neonatal screening already exists.
A study of congenital toxoplasmosis with particular emphasis on clinical manifestations, sequelae, and therapy.
Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis.
Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review.
High prevalence of congenital toxoplasmosis in Brazil estimated in a 3-year prospective neonatal screening study.
Recent trends in research on congenital toxoplasmosis.
However, the effect of prenatal treatment on these outcomes is unclear (2), and the best method for preventing and controlling congenital toxoplasmosis is controversial.
The symptoms of congenital toxoplasmosis include abnormal changes in head size (hydrocephaly or microcephaly), intracranial calcifications, deafness, seizures, cerebral palsy, damage to the retina, and mental retardation.
Our study and those of others recently published on congenital toxoplasmosis in Brazil (17,18) implicate toxoplasmosis as an important health problem.
The fetal lesions closely resembled those in congenital toxoplasmosis (7).

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