Wallis et al., "Mixed epithelial and stromal tumor of the kidney lacks the genetic alterations of cellular congenital mesoblastic nephroma
," Human Pathology, vol.
Among 20(18.87%) cases of malignant neoplastic lesions, 12(11.32%) were renal cell carcinoma, 5(4.72%) were Wilm's tumor, 1(0.94%) case each of clear cell sarcoma kidney, congenital mesoblastic nephroma & transitional cell carcinoma.
Another rare case in our study was congenital mesoblastic nephroma operated in 11 day old infant, with history of maternal hydramnios, premature birth, abdominal mass.
Stromal predominant entities such as congenital mesoblastic nephroma
and primary renal synovial sarcoma can be considered as differential diagnoses of MEST.
(5.) Drut R: Multicystic congenital mesoblastic nephroma
. Int J Surg Pathol 2002; 10:59-63.
Renal leiomyiomas may be triggered by a genetic predisposition followed by an acquired insult.[sup.4] Carpenter and colleagues demonstrated breakpoints in the q13-15 region of chromosome 12 in leiomyomas and congenital mesoblastic nephroma
.[sup.5] Tsujimura and colleagues suggested an association between tuberous sclerosis and renal leiomyomas.[sup.6] Moreover, Krishnan and colleagues showed that Epstein-Barr virus infection could also lead to renal leiomyomas in immunocompromised patients.[sup.7]
(2) Other renal tumors of childhood have been associated with recurring genetic abnormalities: deletion or mutations of WT1 and p53 in some Wilms tumors, t (12;15) creating the ETV6-NTRK3 fusion gene in congenital mesoblastic nephroma
, and INI1 deletions or mutations in malignant rhabdoid tumors.
Hydramnios associated with congenital mesoblastic nephroma
: case report.