congenital leukemia

congenital leukemia

Pediatric hematology A leukemia that develops in the first month of life, usually acute non-lymphocytic leukemia; CL is often associated with congenital malformations and chromsome defects, especially trisomy 21/Down syndrome, but also trisomy 13, mosaic trisomy 9, monosomy 11, Turner syndrome, etc. See Leukemia.
References in periodicals archive ?
Congenital leukemia (CL) is an uncommon myeloproliferative disorder of the newborn, with an incidence of 4.3-8.6 per million live births [1].
Congenital leukemia (CL) is an extremely rare pathology, with a high mortality rate.
Congenital leukemia is associated with certain genetic pathological entities such as Down syndrome, Turner syndrome or Klippel-Feil syndrome [10].
The treatment of congenital leukemia means exposure of the newborn to toxic chemotherapeutic agents.
It is most often reported in congenital leukemia and AML.
(2) Atypical signs reported in trisomy 9 patients include hemivertebra, (3) holoprosencephaly, (4) sex reversal, (5) an unexpectedly normal psychomotor development, (6) no evident external or internal congenital anomalies and congenital leukemia. (7) Partial trisomy 9p cases have been also reported with dysmorphic features, congenital anomalies, severe mental retardation and gross delay in speech.
Congenital leukemia associated with mosaic trisomy 9.
MANAGEMENT: Although the severe lymphocytosis could be related to a neonatal viral infection or early pertussis, you suspect that this 2-month-old infant may have congenital leukemia, but the incidence of this cancer is only 1 per 500,000 children.

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