Future Research Directions for Autoimmune-associated Fetal Congenital Heart Block
Brito-ZerAaAaAeA n P, Izmirly PM, Ramos-Casals M, Buyon JP, Khamashta M The clinical spectrum of autoimmune congenital heart block. Nat Rev Rheumatol 2015;11:301-12.
What is the suspected mechanism of congenital heart block resulting from anti-Ro antibodies?
* Congenital heart block is a rare disorder, usually associated with maternal transfer of antinuclear antibodies, especially those against Ro.
Prospective evaluation of fetuses with autoimmune associated congenital heart block
followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study.
In some cases, however, congenital heart block
occurs in affected fetuses, causing permanent heart damage and fetal death.
The initiation of dexamethasone or plasmapheresis as a preventative measure against congenital heart block
in high-risk pregnant women is currently under consideration but is not yet justified.3
Complete Congenital Heart block
(CCHB) is a rare cause of neonatal bradycardia with incidence of 1:20,000 live births.
Liam was diagnosed with a lifethreatening congenital heart block
while still in the womb.
NEW YORK -- Exposure to maternal lupus autoantibodies confers a risk of congenital heart block
and neonatal lupus on the fetus, but the risk is small, and no medical treatment is currently recommended, Jill P.
Most fetuses with cardiac anomalies can be delivered vaginally The few exceptions are those with fetal hydrops, congenital heart block
, or arrhythmia; these conditions make it very difficult to monitor the fetus' well-being during labor.
Congenital heart block
is a significant permanent effect of neonatal lupus in offspring of anti-Ro--positive women.