amaurosis

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amaurosis

 [am″aw-ro´sis]
loss of sight without apparent lesion of the eye, as from disease of the optic nerve, spine, or brain.
amaurosis conge´nita (amaurosis congenita of Leber) (congenital amaurosis) hereditary blindness occurring at or shortly after birth, associated with an atypical form of diffuse pigmentation and commonly with optic atrophy and attenuation of the retinal vessels.
amaurosis fu´gax sudden temporary or fleeting blindness.
Leber's congenital amaurosis amaurosis congenita.

am·au·ro·sis

(am-aw-rō'sis),
Blindness, especially that occurring without apparent change in the eye itself, as from a brain lesion.
[G. amauros, dark, obscure, + -osis, condition]

amaurosis

/am·au·ro·sis/ (am″aw-ro´sis) blindness, especially that occurring without apparent lesion of the eye.amaurot´ic
amaurosis conge´nita of Leber , congenital amaurosis a form of hereditary blindness, occurring at or shortly after birth, associated with an atypical form of diffuse pigmentation and commonly with optic atrophy and attenuation of the retinal vessels.

amaurosis

(ăm′ô-rō′sĭs)
n.
Total loss of vision, especially when occurring without pathological changes to the eye.

am′au·rot′ic (-rŏt′ĭk) adj.

amaurosis

[am′ôrō′sis]
Etymology: Gk, amauroein, to darken
blindness, especially lack of vision resulting from a systemic cause such as disease of the optic nerve or brain, diabetes, renal disease, acute gastritis, or systemic poisoning produced by excessive use of alcohol or tobacco, rather than from damage to the eye itself. Unilateral or, more rarely, bilateral amaurosis may follow an emotional shock and may continue for days or months. One kind of congenital amaurosis is transmitted as an autosomal-recessive trait. amaurotic, adj.

amaurosis

Blindness, see there.

am·au·ro·sis

(am'aw-rō'sis)
Blindness, especially that form occurring without apparent change in the eye itself, as from a brain lesion.
[G. amauros, dark, obscure, + -osis, condition]

amaurosis

An old-fashioned term for blindness. From the Greek amaurois , dark or obscure. See also AMAUROSIS FUGAX.

amaurosis 

1. Partial or total loss of sight due to a lesion somewhere in the visual pathway (usually the optic nerve), but not in the eye itself.
2. Synonym for blindness.

amaurosis

loss of sight without apparent lesion of the eye, as from disease of the optic nerve, spine or brain.
References in periodicals archive ?
Different functional outcome of RetGC1 and RPE65 gene mutations in Leber congenital amaurosis.
A review of the Leber Congenital Amaurosis (LCA) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
Further, RP may occur associated with various genetic disorders such as: Usher syndrome (3); Leber congenital amaurosis (4); Bardet-Biedl syndrome (5); Alstrom disease (6); and Phytanic acid storage disease (7) to name a few.
The human condition, called Leber congenital amaurosis (LCA), results in degeneration of the retina and near total blindness in infancy.
The AAV delivery system is successfully being used in clinical trials of Leber congenital amaurosis gene therapy that have restored vision in more than 50 adults and children who were virtually blind.
Facing a race against time before she loses her sight, Renee Dooley does not let her condition - leber congenital amaurosis - hold her back.
a leading genome editing company, today announced results from a pre-clinical study in transgenic mice demonstrating dose-dependent, in vivo editing using EDIT-101, Editas Medicines pre-clinical product candidate for the treatment of Leber Congenital Amaurosis type 10 (LCA10).
USPRwire, Tue Jan 19 2016] Global Markets Direct's, 'Leber Congenital Amaurosis (LCA) - Pipeline Review, H2 2015', provides an overview of the Leber Congenital Amaurosis (LCA)'s therapeutic pipeline.
The product is used to treat nyctalopia, or night blindness, in patients with Leber's congenital amaurosis due to mutations in the RPE65 gene.
Genzyme, a Sanofi company, has established a research collaboration with the University of Florida and the University of Pennsylvania to develop a gene therapy for the treatment of Leber congenital amaurosis type 1 (LCA-1), rare genetic disease that causes childhood blindness.
The ocular-plus blind group (n = 22) included children with ROP (n = 5), Leber's congenital amaurosis (n = 13), Nome's disease (n = 2), optic nerve hypoplasia (n = 1), and optic nerve atrophy (n = 1).
Washington, July 30 ( ANI ): Scientists have isolated an elusive human gene that causes a common form of Leber congenital amaurosis (LCA), a relatively rare but devastating form of early-onset blindness.

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