congenic strains

congenic strains

Strains of animals, such as rats, that are genetically identical except for a single chromosome segment. If such strains show differences in disease or other characteristics, the locus for these features must be within that segment. Important genetic research can be done using congenic strains.
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Positional cloning using interval-specific congenic strains narrowed this QTL to a 0.
Because the DBA/2J and C57BL/6J mice that were used to generate the interval-specific congenic strains differ significantly in the brain levels of some oxidative stress markers (Rebrin et al.
1) Congenic and interval-specific congenic strains refer to genetic animal models that are genetically identical to noncongenic (wild type) counterparts except for a limited genetic region (the congenic interval, which can range in size from moderately large to as small as 1 megabase).
Classical congenic strains typically are derived from two inbred progenitor strains (i.
Interval-specific congenic strains (ISCS): An experimental design for mapping a QTL into a 1-centimorgan interval Mammalian Genome 8:163-167, 1997.
The strain's fertility was investigated, according to Kwon-Chung (7), by crossing the isolate with reference serotype A strains H99 (MAT[alpha]) and IUM 96-2828 (MATa), and with serotype D congenic strains JEC20 (MATa) and JEC21 (MAT[alpha]).
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah non-responsive C57BL/6J mice.
Estimates have been made of how much heterozygosity remains in congenic strains, depending on the number of backcrosses used to produce them.
The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes (Anny Fortin, Eduardo Diez, Janet E.
After repeated backcrosses, the congenic strains carry the DNA of the recipient strain except for one relatively small piece of DNA that is still derived from the second parental inbred strain (i.
models called interval-specific congenic strains [ISCS] and advanced intercross lines [AIL]) as well as of heterogeneous populations (see Palmer and Phillips 2002).
Using this strategy, one can produce several congenic strains that carry different or overlapping parts of the original QTL.