[C3H-14.sup.NSY] mice and their congenic strains were administered a single high dose of STZ, and the STZ sensitivities of these strains were compared with those of the parental strains.
In our previous study, we established two congenic strains in which limited segments of NSY-Chr14 were introgressed onto control C3H background genes .
Traditional genetic analysis in the OLETF has been based on mapping QTL using microsatellite markers, followed by genetic isolation of QTL in congenic strains .
Matsumoto, "Fine mapping of the hyperglycemic and obesity QTL by congenic strains suggests multiple loci on rat chromosome 14," The Journal of Medical Investigation, vol.
Positional cloning using interval-specific congenic strains
narrowed this QTL to a 0.44-Mb interval syntenic with human chromosome 1q23.2 (Kozell et al.
KEY WORDS: Genetic theory of alcohol and other drug use; genetics and heredity; behavioral phenotypes, genetic trait, quantitative traits; quantitative trait locus (QTL), QTL mapping; congenics; interval-specific congenics (ISCs); congenic strains
; animal models
The strain's fertility was investigated, according to Kwon-Chung (7), by crossing the isolate with reference serotype A strains H99 (MAT[alpha]) and IUM 96-2828 (MATa), and with serotype D congenic strains
JEC20 (MATa) and JEC21 (MAT[alpha]).
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains
of Ah responsive and Ah non-responsive C57BL/6J mice.
All of the mate preference tests were designed to take advantage of the power of congenic strains
: essentially the only genetic difference between males that marked the territories and, in some versions participated directly in the test, was [Abpa.sup.a] and [Abpa.sup.b].
After repeated backcrosses, the congenic strains
carry the DNA of the recipient strain except for one relatively small piece of DNA that is still derived from the second parental inbred strain (i.e., the donor strain).
Finer mapping of a QTL to the smallest possible genetic segment may involve the use of specialized genetic models (e.g., models called interval-specific congenic strains
[ISCS] and advanced intercross lines [AIL]) as well as of heterogeneous populations (see Palmer and Phillips 2002).
Using this strategy, one can produce several congenic strains
that carry different or overlapping parts of the original QTL.