congenic strain

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con·gen·ic strain

an inbred strain of animals produced by continued crossing of a gene of one line onto another inbred (isogenic) line.
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Katsuta et al., "Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Leprfa) rat," Biochemical and Biophysical Research Communications, vol.
Standard inbred and congenic strain analyses suggested that lower Mpdz expression and/or certain variations in the amino acid sequence of the encoded MPDZ protein were associated with more severe ethanol withdrawal (Fehr et al.
Animals from the starting congenic strain are backcrossed to background strain animals to create first-generation offspring (N1), which are then backcrossed to the background strain.
Previously we demonstrated that one of the hyperglycemic QTLs, Niddm20 (Nidd2/of as our original nomenclature), located on chromosome 14 of the OLETF rat, is quite unique for the following reasons: (1) its LOD score (4.07 for 30 min postprandial plasma glucose) is one of the highest among the other QTLs [35, 36]; (2) there is a strong epistasis with other QTLs [37]; (3) most importantly it interacts with the obese condition: the congenic strain exhibits more severe diabetic symptoms when combined with either genetically or nutritionally induced obesity [38, 39].
Genes that affect the shape of the murine mandible: congenic strain analysis.
[C3H-14.sup.NSY] mice and their congenic strains were administered a single high dose of STZ, and the STZ sensitivities of these strains were compared with those of the parental strains.
The strain's fertility was investigated, according to Kwon-Chung (7), by crossing the isolate with reference serotype A strains H99 (MAT[alpha]) and IUM 96-2828 (MATa), and with serotype D congenic strains JEC20 (MATa) and JEC21 (MAT[alpha]).
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah non-responsive C57BL/6J mice.
All of the mate preference tests were designed to take advantage of the power of congenic strains: essentially the only genetic difference between males that marked the territories and, in some versions participated directly in the test, was [Abpa.sup.a] and [Abpa.sup.b].
After repeated backcrosses, the congenic strains carry the DNA of the recipient strain except for one relatively small piece of DNA that is still derived from the second parental inbred strain (i.e., the donor strain).
Finer mapping of a QTL to the smallest possible genetic segment may involve the use of specialized genetic models (e.g., models called interval-specific congenic strains [ISCS] and advanced intercross lines [AIL]) as well as of heterogeneous populations (see Palmer and Phillips 2002).