conformational epitope

conformational epitope

Adjacent amino acid strings at different points in a folded protein, making a complex site to which an antibody can bind. Conformational epitopes are less stable than LINEAR EPITOPES, a fact that explains why some allergies are outgrown in time. Allergies, such as peanut allergy, in which the antibody (IgE) binds to a linear epitope tend to persist.
References in periodicals archive ?
PankoMab-GEX is an investigational monoclonal antibody that enables tumor-specific binding to a novel carbohydrate-induced conformational epitope, the TA-MUC1, which is extensively expressed in many tumor types including ovarian, lung and breast.
sup][10] Researchers further revealed that the polypeptide was a conformational epitope that was not accessible in the full-size SmD1 protein.
10) Although potential binding sites have been identified through the knowledge obtained from the crystal structure of AQP-4, it is not clear yet whether these antibodies recognize a linear or a conformational epitope.
The monoclonal antibody mAb 162 recognizes a conformational epitope on p80/p70 heterodimer.
Utilizing a proprietary platform to identify novel targets and design drugs against these targets, Visterra has identified a unique conformational epitope on the stem region of the influenza hemagglutinin (HA) protein, mapped by peptide scanning, that is not only conserved across all influenza subtypes, but is also resistant to virus mutation.
This MAb was shown to recognize a conformational epitope of HA2 (36), but no immunogen that could selectively induce this response has been described.
Three MAbs (3F2D8, 8F9A8 and 5F 19G11) recognize linear epitopes, while the remaining MAb (1F4C4) reacts with a conformational epitope located on heavy chain of all IgG subclasses.
VIS410 is designed to identify a conformational epitope on the stem region of influenza hemagglutinin (HA) protein which is not conserved across all influenza A strains and is opposed to virus mutation.
The mAb M3-specific conformational epitope was identified and localized in the region of amino acids 1-69 on the N protein.
2) Three IgG1, 2, 3 specific MAbs of which two (2F7G8 and 1F8G4) react with linear epitopes and the third one (7F 14F7) reacts with conformational epitope located on heavy chain of IgGl, 2, 3 subclasses (Figure 2).
In addition, a common conformational epitope has been identified in the center of the N-protein (AA51-69), which exhibits 84% amino acid identity between Lelystad virus and VR-2332 (Figure 3).