Beta-amyloid constitutes an important target for disease-modification of Alzheimer's disease, a so-called conformational disease
Through our disease relevant technology, or DRT, platform which was established on our understanding of the proteostasis network, we have explored developing drug candidates for a variety of protein conformational diseases
The Nature Chemical Biology paper is titled "Small-Molecule Proteostasis Regulators for Protein Conformational Diseases
Alpha1-antitrypsin deficiency: a model for conformational diseases
They have found a process by which proteins with a tendency to cause conformational diseases
such as amyotrophic lateral sclerosis, familial amyloidotic polyneuropathy, familial amyloidotic cardiomyopathy, etc.
Alpha1-antitrypsin deficiency--a model for conformational diseases
In recent years our understanding of the nature of spontaneous protein aggregation has increased greatly because of its importance in the pathogenesis of conformational diseases
such as amyloidosis, Alzheimer's disease and the spongieform encephalopathies.
Identification of bistable network topologies associated with toxic aggregation thresholds found in conformational diseases
Stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER) is observed in many diseases which are now recognized as protein conformational diseases
, including genetic diseases, neurodegenerative diseases, and retinal degenerative diseases.
Alpha, antitrypsin deficiency--a model for conformational diseases
Alpha-l-antitrypsin deficiency--a model for conformational diseases