conformation

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con·for·ma·tion

(kon'fōr-mā'shŭn),
The spatial arrangement of a molecule achieved by rotation of groups about single covalent bonds, without breaking any covalent bonds; the latter restriction differentiates conformation from configuration (as in anomers and related stereoisomers) where a bond or bonds must be broken in going from one form (configuration) to another. Conformation is one of the most important aspects of sugar chemistry and is basic to an understanding of the chemical properties of sugars. Compare: configuration.
Farlex Partner Medical Dictionary © Farlex 2012

con·for·ma·tion

(kon'fōr-mā'shŭn)
The spatial arrangement of a molecule achieved by rotation of groups about single covalent bonds, without breaking any covalent bonds.
Compare: configuration
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

conformation

(kŏn″for-mā′shŭn)
The form or shape of a part, body, material, or molecule.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Therefore, it seems that the orientation of n-butyryl group with 2,4,6-trimethylbenzenesulfonyl moiety exerts a significant effect on the conformational preferences of the compound 3 and this behaviour may be attributed to a combination of steric and electronic factors.
Because the analysis of [PrP.sup.Sc] from sheep prion isolates by CSSA showed an extremely high conformational stability of BSE samples, we improved the Istituto Superiore di Sanita discriminatory WB by including a pretreatment of brain homogenates with GdnHCl.
We used heat denaturation of the fusion proteins tethered to the EBY100 yeast cell surface to categorize the specific linear and conformational SARS-CoV N protein mAb epitopes (35, 36).
At the [beta]Ala93 site, water molecules did not replace the cysteine side chain, and the alanine substitution increased the conformational freedom of [beta]His146, weakening the important interaction of this residue with [beta]Asp94.
It can either be utilized, as in polymer synthesis, or be dissipated as heat, making the conformational change nearly irreversible.
This leads to a different crystallization throughout the whole volume and consequently to conformational changes that could be followed by means of spectroscopic techniques.
To understand how individual protein molecules respond to thermal noise, we have studied dynamic changes of the conformational state of proteins using single molecule imaging.
Also, it allows studying conformational variability of macromolecular complexes by determining their different conformations [17-22].
(13,17,18) If microgravity exposure primarily induces alterations in local ventricular geometry and wall stress through conformational changes in the overall shape of the heart, then a general remodeling of myocardium might also occur.
The book also examines the role of the proteostasis network in protein conformational diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and cystic fibrosis.