concentration-effect curve

concentration-effect curve

Pharmacology A graph of the relationship between exposure concentration of a drug or other chemical and the graded effect that it produces. See Area under the curve concentration.
References in periodicals archive ?
terebinthifolius Bark Extract, Hydroxyzine, or Their Association on the Concentration-Effect Curve to Histamine.
terebinthifolius Bark Extract on the Concentration-Effect Curve to 2-Pyridylethylamine.
At a lower dose (250 [micro]g/mL), the extract induced a parallel shift to the right of the concentration-effect curve to histamine, thereby suggesting a surmountable antagonism.
First, a concentration-effect curve was constructed by adding verapamil to the steady-state contraction induced by 60 mM [K.sup.+].
Rightward displacement of the concentration-effect curve in response to ACh was also observed in tracheal rings maintained in increasing concentrations of [beta]-citronellol (Figure 2D).
In the steady state of a given sustained contraction, concentration-effect curves were obtained by exposing preparations to increasing concentrations of [beta]-citronellol, which was added cumulatively to the organ bath (12 min for each concentration).
In addition, PA (3 [micro]M) depressed almost half of the maximum response of NE concentration-effect curve (p < 0.05), exhibiting a non-competitive antagonism (Fig.
Ritanserin alone did not change the arterial tension nor the concentration-effect curve of SdD (Fig.
The [CC.sub.50] was calculated from concentration-effect curves after nonlinear regression analysis (Boltzmann sigmoidal Origin 6.0).
The [CC.sub.50] values were calculated from concentration-effect curves after nonlinear regression analysis based on Boltzmann sigmoidal curve by the software Graph Pad Prism 5.0.
We used the single agent concentration-response relationships shown in Figure 1 to predict concentration-effect curves for mixtures of all four agents, assuming additive combination effects.
The standard analysis of the concentration-effect curves via the sigmoid [E.sub.max] model (Holford and Sheiner, 1981) does not take into account the intra-individual correlations, which result on the one hand from repeated measurements of a sample at different concentrations, and on the other hand from the duplicate measurements of preparations from a single animal.